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西他沙星
Tier C — Watch / tradeSitafloxacin Hydrate
第一三共株式会社
Originator
2008
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：Topoisomerase IV、Bacterial DNA gyrase
Brand：Gracevit
Indications (approved)：膀胱炎、鼻窦炎、扁桃体炎、肺炎、宫颈炎、冠周炎、颌骨疾病、喉炎
Regional status
US
-
EU
-
China
批准上市
2019-02-01
Japan
批准上市
2008-01-25
Synthetic routes & intermediates4 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 18 · Total yield 7.35 g
| Code | CAS No. | Intermediate |
|---|---|---|
| SITAF-001 | 101987-86-4Available | ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate |
| SITAF-002 | 101987-87-5Available | (Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate |
| SITAF-003 | 127199-16-0Available | tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate |
| SITAF-004 | 1470024-56-6Available | ethyl (Z)-2-(3-chloro-2,4,5-trifluorobenzoyl)-3-(((1R,2S)-2-fluorocyclopropyl)amino)acrylate |
| SITAF-005 | 127199-25-1Available | ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| SITAF-006 | 127199-27-3Available | 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| SITAF-007 | - | - |
| SITAF-008 | 147782-16-9Available | 7-((S)-7-((tert-butoxycarbonyl)amino)-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| SITAF-009 | 156816-78-3Available | 2-fluorocyclopropane-1-carboxylic acid |
| SITAF-010 | 3886-69-9Available | (R)-1-phenylethan-1-amine |
| SITAF-011 | 1382850-61-4Available | 2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide |
| SITAF-012 | 1382850-61-4Available | 2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide |
| SITAF-013 | 127199-14-8Available | (1S,2S)-2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide |
| SITAF-014 | 141-97-9Available | ethyl 3-oxobutanoate |
| SITAF-015 | 106-93-4Available | 1,2-dibromoethane |
| SITAF-016 | 32933-03-2Available | ethyl 1-acetylcyclopropane-1-carboxylate |
| SITAF-017 | 129306-05-4Available | ethyl 1-(2-bromoacetyl)cyclopropane-1-carboxylate |
| SITAF-018 | 127199-37-5Available | (R)-5-(1-phenylethyl)-5-azaspiro[2.4]heptane-4,7-dione |
| SITAF-019 | 129306-14-5Available | (R,Z)-7-(hydroxyimino)-5-(1-phenylethyl)-5-azaspiro[2.4]heptan-4-one |
| SITAF-020 | 127199-38-6Available | (S)-7-amino-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-4-one |
| SITAF-021 | 127199-41-1Available | (S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine |
| SITAF-022 | 127199-42-2Available | tert-butyl ((S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)carbamate |
OptimisedRoute 2Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| SITAF-003 | 127199-16-0Available | tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate |
| SITAF-023 | 23364-44-5Available | (1S,2R)-2-amino-1,2-diphenylethan-1-ol |
| SITAF-024 | 17341-93-4Available | 2,2,2-trichloroethyl carbonochloridate |
| SITAF-025 | 86286-50-2Available | (4R,5S)-4,5-diphenyloxazolidin-2-one |
| SITAF-026 | 534-15-6Available | 1,1-dimethoxyethane |
| SITAF-027 | 142977-50-2Available | (4R,5S)-3-(1-methoxyethyl)-4,5-diphenyloxazolidin-2-one |
| SITAF-028 | 143059-81-8Available | (4R,5S)-4,5-diphenyl-3-vinyloxazolidin-2-one |
| SITAF-029 | 142977-51-3Available | (4R,5S)-3-((1R,2S)-2-fluorocyclopropyl)-4,5-diphenyloxazolidin-2-one |
| SITAF-030 | 141042-21-9Available | (1R,2S)-2-fluorocyclopropan-1-amine hydrochloride |
OptimisedRoute 3Steps 8 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| SITAF-003 | 127199-16-0Available | tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate |
| SITAF-030 | 141042-21-9Available | (1R,2S)-2-fluorocyclopropan-1-amine hydrochloride |
| SITAF-031 | 98-84-0Available | 1-phenylethan-1-amine |
| SITAF-032 | 1263004-45-0Available | N-(1-phenylethyl)ethenamine |
| SITAF-033 | 142977-29-5Available | (1-phenylethyl)(vinyl)carbamic chloride |
| SITAF-034 | 142977-33-1Available | benzyl (1-phenylethyl)(vinyl)carbamate |
| SITAF-035 | 142977-39-7Available | benzyl (2-fluorocyclopropyl)(1-phenylethyl)carbamate |
| SITAF-036 | 1314933-35-1Available | 2-fluorocyclopropan-1-amine hydrochloride |
| SITAF-037 | 14602-86-9Available | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl carbonochloridate |
| SITAF-038 | 142977-48-8Available | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ((1R,2S)-2-fluorocyclopropyl)carbamate |
OptimisedRoute 4Steps 8 · Total yield 383.3 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| SITAF-007 | - | - |
| SITAF-015 | 106-93-4Available | 1,2-dibromoethane |
| SITAF-039 | 17136-36-6Available | benzylglycine |
| SITAF-040 | 76315-01-0Available | N-benzyl-N-(tert-butoxycarbonyl)glycine |
| SITAF-041 | 6148-64-7Available | potassium 3-ethoxy-3-oxopropanoate |
| SITAF-042 | 207554-16-3Available | ethyl 4-(benzyl(tert-butoxycarbonyl)amino)-3-oxobutanoate |
| SITAF-043 | 207554-17-4Available | ethyl 1-(N-benzyl-N-(tert-butoxycarbonyl)glycyl)cyclopropane-1-carboxylate |
| SITAF-044 | 129306-04-3Available | 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione |
| SITAF-045 | 180506-32-5Available | (S)-5-benzyl-7-hydroxy-5-azaspiro[2.4]heptan-4-one |
| SITAF-046 | 144282-35-9Available | (S)-5-benzyl-5-azaspiro[2.4]heptan-7-amine |
| SITAF-047 | 144282-37-1Available | tert-butyl (S)-(5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbamate |
Frequently asked questions
What are the approved indications of Sitafloxacin Hydrate?
Approved indications include: 膀胱炎, 鼻窦炎, 扁桃体炎, 肺炎, 宫颈炎, 冠周炎, 颌骨疾病, 喉炎.
When does the Sitafloxacin Hydrate patent expire?
No public expiry year is available for Sitafloxacin Hydrate yet; this page updates once verified.
How many synthesis routes are recorded for Sitafloxacin Hydrate?
4 synthesis routes are recorded; the shortest is 6 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Sitafloxacin Hydrate intermediates?
45 intermediate CAS of Sitafloxacin Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Sitafloxacin Hydrate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24