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CAS 1382850-61-4
2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide
Codes：SITAF-011、SITAF-012
Application context (from source-drug indications)
膀胱炎西他沙星鼻窦炎西他沙星扁桃体炎西他沙星肺炎西他沙星宫颈炎西他沙星冠周炎西他沙星
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 西他沙星Sitafloxacin Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate→(Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate→tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate→ethyl (Z)-2-(3-chloro-2,4,5-trifluorobenzoyl)-3-(((1R,2S)-2-fluorocyclopropyl)amino)acrylate→ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate→8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→SITAF-007→7-((S)-7-((tert-butoxycarbonyl)amino)-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→2-fluorocyclopropane-1-carboxylic acid→(R)-1-phenylethan-1-amine→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→(1S,2S)-2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→ethyl 3-oxobutanoate→1,2-dibromoethane→ethyl 1-acetylcyclopropane-1-carboxylate→ethyl 1-(2-bromoacetyl)cyclopropane-1-carboxylate→(R)-5-(1-phenylethyl)-5-azaspiro[2.4]heptane-4,7-dione→(R,Z)-7-(hydroxyimino)-5-(1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-7-amino-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine→tert-butyl ((S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)carbamate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.