苹果酸舒尼替尼

Tier B — Position early

Sunitinib Malate

辉瑞

Originator

2006

First approval

Expiry (public)

$1.24B ▲

Peak sales

化学药

Type

Targets：VEGFR1、KIT、VEGFR3、CSF1R、PDGFR-β、VEGFR2、FLT3、PDGFR-α、RET

Brand：Sutent、索坦

Indications (approved)：胰腺神经内分泌肿瘤、肾细胞癌、胃肠道间质瘤

Regional status

批准上市

2006-01-26

批准上市

2006-07-19

China

批准上市

2007-10-30

Japan

批准上市

2008-04-16

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 216 g

Code	CAS No.	Intermediate
SUNT-001	674-82-8 Available	4-methyleneoxetan-2-one
SUNT-002	100-36-7 Available	N1,N1-diethylethane-1,2-diamine
SUNT-003	590424-03-6 Available	N-(2-(diethylamino)ethyl)-3-oxobutanamide
SUNT-004	1694-31-1 Available	tert-butyl 3-oxobutanoate
SUNT-005	590424-04-7 Available	tert-butyl 4-((2-(diethylamino)ethyl)carbamoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
SUNT-006	590424-05-8 Available	N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-007	3724-43-4 Available	N-(chloromethylene)-N-methylmethanaminium chloride
SUNT-008	356068-86-5 Available	N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-009	56341-41-4 Available	5-fluoroindolin-2-one
SUNT-010	97-67-6 Available	(S)-2-hydroxysuccinic acid

OptimisedRoute 3Steps 3 · Total yield /

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
SUNT-002	100-36-7 Available	N1,N1-diethylethane-1,2-diamine
SUNT-006	590424-05-8 Available	N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-014	2199-51-1 Available	ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-017	17106-13-7 Available	2,4-dimethyl-1H-pyrrole-3-carboxylic acid
SUNT-018	52508-87-9 Available	5-fluoro-2-oxoindoline-3-carbaldehyde

OptimisedRoute 4Steps 8 · Total yield 0.6 g

Synthetic routes & intermediates Route 4

Code	CAS No.	Intermediate
SUNT-002	100-36-7 Available	N1,N1-diethylethane-1,2-diamine
SUNT-008	356068-86-5 Available	N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-012	141-97-9 Available	ethyl 3-oxobutanoate
SUNT-014	2199-51-1 Available	ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-015	2199-59-9 Available	ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-016	253870-02-9 Available	5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
SUNT-019	2436-79-5 Available	diethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
SUNT-020	5442-91-1 Available	4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
SUNT-021	1257262-45-5 Available	diethyl (2-((4-fluoro-2-iodophenyl)amino)-2-oxoethyl)phosphonate
SUNT-022	1257262-48-8 Available	(Z)-N-(2-(diethylamino)ethyl)-5-(3-((4-fluoro-2-iodophenyl)amino)-3-oxoprop-1-en-1-yl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-023	61272-76-2 Available	4-fluoro-2-iodoaniline
SUNT-024	79-04-9 Available	2-chloroacetyl chloride
SUNT-025	1257262-44-4 Available	2-chloro-N-(4-fluoro-2-iodophenyl)acetamide
SUNT-026	122-52-1 Available	triethyl phosphite

OptimisedRoute 5Steps 6 · Total yield 12 g

Synthetic routes & intermediates Route 5

Code	CAS No.	Intermediate
SUNT-002	100-36-7 Available	N1,N1-diethylethane-1,2-diamine
SUNT-009	56341-41-4 Available	5-fluoroindolin-2-one
SUNT-010	97-67-6 Available	(S)-2-hydroxysuccinic acid
SUNT-012	141-97-9 Available	ethyl 3-oxobutanoate
SUNT-015	2199-59-9 Available	ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-019	2436-79-5 Available	diethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
SUNT-020	5442-91-1 Available	4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
SUNT-027	951661-94-2 Available	ethyl (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

ProcessRoute 2Steps 8 · Total yield 1.7 kg

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
SUNT-002	100-36-7 Available	N1,N1-diethylethane-1,2-diamine
SUNT-004	1694-31-1 Available	tert-butyl 3-oxobutanoate
SUNT-008	356068-86-5 Available	N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
SUNT-009	56341-41-4 Available	5-fluoroindolin-2-one
SUNT-010	97-67-6 Available	(S)-2-hydroxysuccinic acid
SUNT-011	14352-65-9 Available	(E)-tert-butyl 2-(hydroxyimino)-3-oxobutanoate
SUNT-012	141-97-9 Available	ethyl 3-oxobutanoate
SUNT-013	86770-31-2 Available	2-(tert-butyl) 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
SUNT-014	2199-51-1 Available	ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-015	2199-59-9 Available	ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
SUNT-016	253870-02-9 Available	5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Frequently asked questions

What are the approved indications of Sunitinib Malate?

Approved indications include: 胰腺神经内分泌肿瘤, 肾细胞癌, 胃肠道间质瘤.

When does the Sunitinib Malate patent expire?

No public expiry year is available for Sunitinib Malate yet; this page updates once verified.

How many synthesis routes are recorded for Sunitinib Malate?

5 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Sunitinib Malate intermediates?

27 intermediate CAS of Sunitinib Malate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Sunitinib Malate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24