马昔腾坦
Tier B — Position earlyMacitentan
Targets：ETAR、ETBR
Brand：Opsumit、傲朴舒、Zependo
Indications (approved)：肺动脉高压
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| MACI-001 | 1878-68-8 | 2-(4-bromophenyl)acetic acid |
| MACI-002 | 41841-16-1 | methyl 2-(4-bromophenyl)acetate |
| MACI-003 | 616-38-6 | dimethyl carbonate |
| MACI-004 | 149506-35-4 | dimethyl 2-(4-bromophenyl)malonate |
| MACI-005 | 6313-33-3 | formimidamide hydrochloride |
| MACI-006 | 706811-25-8 | 5-(4-bromophenyl)pyrimidine-4,6-diol |
| MACI-007 | 146533-41-7 | 5-(4-bromophenyl)-4,6-dichloropyrimidine |
| MACI-008 | - | potassium (N-propylsulfamoyl)amide |
| MACI-009 | 1393813-42-7 | - |
| MACI-010 | 107-21-1Available | ethane-1,2-diol |
| MACI-011 | 1393813-43-8 | - |
| MACI-012 | 32779-36-5 | 5-bromo-2-chloropyrimidine |
| MACI-013 | 1189-71-5 | sulfurisocyanatidic chloride |
| MACI-014 | 75-65-0 | 2-methylpropan-2-ol |
| MACI-015 | - | tert-butyl chlorosulfonylcarbamate |
| MACI-016 | 107-10-8 | propan-1-amine |
| MACI-017 | 1393813-40-5 | tert-butyl N-propylsulfamoylcarbamate |
| MACI-018 | 147962-41-2 (free) | - |
| Code | CAS No. | Intermediate |
|---|---|---|
| MACI-007 | 146533-41-7 | 5-(4-bromophenyl)-4,6-dichloropyrimidine |
| MACI-009 | 1393813-42-7 | - |
| MACI-011 | 1393813-43-8 | - |
| MACI-012 | 32779-36-5 | 5-bromo-2-chloropyrimidine |
| MACI-013 | 1189-71-5 | sulfurisocyanatidic chloride |
| MACI-016 | 107-10-8 | propan-1-amine |
| MACI-019 | 147962-41-2 | - |
| MACI-020 | 7580-85-0 | 2-(tert-butoxy)ethanol |
Frequently asked questions
What are the approved indications of Macitentan?
Approved indications include: 肺动脉高压.
When does the Macitentan patent expire?
No public expiry year is available for Macitentan yet; this page updates once verified.
How many synthesis routes are recorded for Macitentan?
2 synthesis routes are recorded; the shortest is 4 steps with 225 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Macitentan intermediates?
1 intermediate CAS of Macitentan are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Macitentan intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24