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CAS 1189-71-5
sulfurisocyanatidic chloride
Codes：MACI-013
Application context (from source-drug indications)
肺动脉高压马昔腾坦肺性高血压马昔腾坦慢性病马昔腾坦慢性血栓栓塞性肺高压马昔腾坦血栓栓塞马昔腾坦心绞痛马昔腾坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马昔腾坦Macitentan | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-bromophenyl)acetic acid→methyl 2-(4-bromophenyl)acetate→dimethyl carbonate→dimethyl 2-(4-bromophenyl)malonate→formimidamide hydrochloride→5-(4-bromophenyl)pyrimidine-4,6-diol→5-(4-bromophenyl)-4,6-dichloropyrimidine→potassium (N-propylsulfamoyl)amide→MACI-009→ethane-1,2-diol→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→2-methylpropan-2-ol→tert-butyl chlorosulfonylcarbamate→propan-1-amine→tert-butyl N-propylsulfamoylcarbamate→MACI-018
5-(4-bromophenyl)-4,6-dichloropyrimidine→MACI-009→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→propan-1-amine→MACI-019→2-(tert-butoxy)ethanol
Intermediates available on this site
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