克立硼罗
Tier C — Watch / tradeCrisaborole
Targets：PDE4
Brand：Eucrisa、舒坦明、Staquis
Indications (approved)：特应性皮炎
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| CRISA-001 | 906673-54-9Available | 4-(4-bromo-3-formylphenoxy)benzonitrile |
| CRISA-002 | 906673-45-8Available | 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile |
| CRISA-003 | 107-30-2Available | chloro(methoxy)methane |
| CRISA-004 | 947162-14-3Available | 4-(4-bromo-3-((methoxymethoxy)methyl)phenoxy)benzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| CRISA-001 | 906673-54-9Available | 4-(4-bromo-3-formylphenoxy)benzonitrile |
| CRISA-005 | 2973-80-0Available | 2-bromo-5-hydroxybenzaldehyde |
| CRISA-006 | 107-21-1Available | ethane-1,2-diol |
| CRISA-007 | 1160182-44-4Available | 4-bromo-3-(1,3-dioxolan-2-yl)phenol |
| CRISA-008 | 1194-02-1Available | 4-fluorobenzonitrile |
Frequently asked questions
What are the approved indications of Crisaborole?
Approved indications include: 特应性皮炎.
When does the Crisaborole patent expire?
No public expiry year is available for Crisaborole yet; this page updates once verified.
How many synthesis routes are recorded for Crisaborole?
2 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Crisaborole intermediates?
8 intermediate CAS of Crisaborole are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Crisaborole intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24