CAS 1194-02-1

4-fluorobenzonitrile

Codes：CRISA-008

Application context (from source-drug indications)

特应性皮炎克立硼罗皮炎克立硼罗湿疹克立硼罗斑秃克立硼罗局部硬皮病克立硼罗斑块银屑病克立硼罗

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
克立硼罗Crisaborole	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

克立硼罗优化路线steps: 2total yield: /

4-(4-bromo-3-formylphenoxy)benzonitrile→2-bromo-5-hydroxybenzaldehyde→ethane-1,2-diol→4-bromo-3-(1,3-dioxolan-2-yl)phenol→4-fluorobenzonitrile

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	2-BROMO-5-HYDROXYBENZALDEHYDE Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-(4-Bromo-3-formyl-phenoxy)-benzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-[4-bromo-3-(hydroxymethyl)phenoxy]benzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	[2-bromo-5-(4-cyanophenoxy)phenyl]methyl acetate Pharmaceutical Intermediates	询价	询价	询价	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.