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非布司他

Tier C — Watch / trade

Febuxostat

帝人株式会社
Originator
2008
First approval
-
Expiry (public)
$0.46B ▲
Peak sales
化学药
Type

Targets：XO

Brand：瑞扬、Febutaz、Feburic、Uloric、Adenuric、Febric、风定宁、优立通

Indications (approved)：高尿酸血症、痛风

Regional status

US
批准上市
2009-02-13
EU
批准上市
2008-04-21
China
批准上市
2018-09-04
Japan
批准上市
2011-01-21

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 295 mg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
FEBU-0013011-34-5Available4-hydroxy-3-nitrobenzaldehyde
FEBU-0023272-08-0Available4-hydroxy-3-nitrobenzonitrile
FEBU-0031532670-75-9Available4-hydroxy-3-nitrobenzothioamide
FEBU-004609-15-4Availableethyl 2-chloro-3-oxobutanoate
FEBU-005144060-67-3Availableethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate
FEBU-00678-77-3Available1-bromo-2-methylpropane
FEBU-007144060-93-5Availableethyl 2-(4-isobutoxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate
FEBU-008160844-75-7Availableethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
OptimisedRoute 2Steps 7 · Total yield 1.3 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
FEBU-004609-15-4Availableethyl 2-chloro-3-oxobutanoate
FEBU-00678-77-3Available1-bromo-2-methylpropane
FEBU-008160844-75-7Availableethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
FEBU-0091761-61-1Available5-bromo-2-hydroxybenzaldehyde
FEBU-010222315-01-7Available5-bromo-2-isobutoxybenzaldehyde
FEBU-011876918-26-2Available5-bromo-2-isobutoxybenzonitrile
FEBU-012876918-32-0Available(3-cyano-4-isobutoxyphenyl)boronic acid
FEBU-01322900-83-0Availableethyl 2-bromo-4-methylthiazole-5-carboxylate
FEBU-01462-56-6Availablethiourea
FEBU-0157210-76-6Availableethyl 2-amino-4-methylthiazole-5-carboxylate
OptimisedRoute 3Steps 8 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
FEBU-008160844-75-7Availableethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
FEBU-016123-08-0Available4-hydroxybenzaldehyde
FEBU-01718962-07-7Available4-isobutoxybenzaldehyde
FEBU-018946743-11-9Available3-bromo-4-isobutoxybenzaldehyde
FEBU-019-(E)-3-bromo-4-isobutoxybenzaldehyde oxime
FEBU-020208665-95-6Available3-bromo-4-isobutoxybenzonitrile
FEBU-021208665-96-7Available3-bromo-4-isobutoxybenzothioamide
FEBU-022144060-96-8Availableethyl 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
FEBU-004609-15-4Availableethyl 2-chloro-3-oxobutanoate
FEBU-00678-77-3Available1-bromo-2-methylpropane
OptimisedRoute 4Steps 5 · Total yield 1.29 g
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
FEBU-004609-15-4Availableethyl 2-chloro-3-oxobutanoate
FEBU-00678-77-3Available1-bromo-2-methylpropane
FEBU-008160844-75-7Availableethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
FEBU-023615-58-7Available2,4-dibromophenol
FEBU-02490869-32-2Available2,4-dibromo-1-isobutoxybenzene
FEBU-025161718-81-6Available4-isobutoxyisophthalonitrile
FEBU-026163597-57-7Available3-cyano-4-isobutoxybenzothioamide

Frequently asked questions

What are the approved indications of Febuxostat?

Approved indications include: 高尿酸血症, 痛风.

When does the Febuxostat patent expire?

No public expiry year is available for Febuxostat yet; this page updates once verified.

How many synthesis routes are recorded for Febuxostat?

4 synthesis routes are recorded; the shortest is 5 steps with 1.29 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Febuxostat intermediates?

25 intermediate CAS of Febuxostat are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Febuxostat intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24