Pilocarpine Hydrochloride
Tier C — Watch / tradePilocarpine Hydrochloride
Targets：mAChRs
Brand：Spersacarpin, PilaSite, Pilocarpina lux, Pilobuc, Pilopine HS, Isopto-<span class="highlightText">pilocarpine</span>, Pilogel, Salagen, Isopto carpine, Pilo, Pilocar
Indications (approved)：闭角型青光眼, Ocular hypertension, Open-angle glaucoma, 瞳孔缩小, Sjögren's syndrome, 虹膜炎, 口腔干燥, Glaucoma
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)115092-6-a | 636-61-3 | (2R)-2-Hydroxysuccinic acid |
| (II)115092-6-a | 70681-41-3 | (R)-2-Hydroxysuccinic acid dimethylester |
| (III)115092-6-a | 75-03-6Available | 1-Iodoethane |
| (IV)115092-6-a | - | Diethyl (2S,3R)-2-methyl-3-hydroxysuccinate |
| (V)115092-6-a | - | Dimethyl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate |
| (VI)115092-6-a | - | Dimethyl (3R)-2-bromo-3-ethylbutanedioate |
| (VII)115092-6-a | 39021-62-0 | 1-Methyl-1H-imidazole-5-carbaldehyde |
| (VIII)115092-6-a | - | Methyl (3S,4S)-4-ethyl-2-(1-methyl-1H-imidazol-5-yl)-5-oxooxolane-3-carboxylate |
| (IX)115092-6-a | - | (2S,3R)-2-Ethyl-4-methoxy-3-[(1-methyl-1H-imidazol-5-yl)methyl]-4-oxobutanoic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)115092-7-a | 123-72-8 | 1-Butanone |
| (II)115092-7-a | 922-68-9 | Glyoxylic acid methyl ester |
| (III)115092-7-a | - | Methyl (2R,3S)-3-formyl-2-hydroxypentanoate |
| (IV)115092-7-a | - | (2S,3R)-2-Ethyl-3-hydroxy-4-methoxy-4-oxobutanoic acid |
| (V)115092-7-a | - | Diethyl (2S,3R)-2-methyl-3-hydroxysuccinate |
| (VI)115092-7-a | - | Dimethyl (2S,3R)-2-ethyl-3-[(4-methylbenzene-1-sulfonyl)oxy]butanedioate |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)115092-8-a | 636-61-3 | (2R)-2-Hydroxysuccinic acid |
| (IIa)115092-8-a | 7554-28-1 | (R)-Diethyl malate |
| (IIb)115092-8-a | 83540-97-0 | (R)-Diisopropyl 2-hydroxysuccinate |
| (III)115092-8-a | 75-03-6Available | 1-Iodoethane |
| (IVa)115092-8-a | - | Diethyl (2S,3R)-2-ethyl-3-hydroxybutanedioate |
| (IVb)115092-8-a | - | Dipropan-2-yl (2S,3R)-2-ethyl-3-hydroxybutanedioate |
| (Va)115092-8-a | - | Diethyl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate |
| (Vb)115092-8-a | - | Dipropan-2-yl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate |
| (VIa)115092-8-a | - | Diethyl (3R)-2-bromo-3-ethylbutanedioate |
| (VIb)115092-8-a | - | Diisopropyl 2-bromo-3(R)-ethyl-butanedioate |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)115092-10-a | - | Methyl (2S)-2-hydroxybutanoate |
| (II)115092-10-a | 542-78-9 | 1,3-Propanedial |
| (III)115092-10-a | - | Methyl (2S)-2-ethyl-3-formyl-4-oxobutanoate |
| (IV)115092-10-a | - | Methyl (2S)-2-ethyl-4-hydroxy-3-(hydroxymethyl)butanoate |
| (V)115092-10-a | - | (3S)-3-Ethyl-4-(hydroxymethyl)oxolan-2-one |
| (VI)115092-10-a | - | 5-Chloro-1-methyl-1H-imidazole |
| (VII)115092-10-a | - | (3S)-3-Ethyl-4-(1-methyl-1H-imidazole-5-carbonyl)oxolan-2-one |
| (VIII)115092-10-a | - | (3S)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| Pilocarpine Nitrate-020 | 99776-32-6 | 2-(2,2-Dimethoxyethyl)propane-1,3-diol |
| Pilocarpine Nitrate-021 | 119117-34-9 | 2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate |
| Pilocarpine Nitrate-022 | 144461-05-2 | (2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate |
| Pilocarpine Nitrate-023 | 144461-06-3 | (2S)-2-Formyl-4,4-dimethoxybutyl acetate |
| Pilocarpine Nitrate-024 | 1826-67-1 | Vinylmagnesium bromide |
| Pilocarpine Nitrate-025 | 1192231-10-9 | (2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol |
| Pilocarpine Nitrate-026 | 1192231-09-6 | (5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one |
| Pilocarpine Nitrate-027 | 144461-10-9 | (3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one |
| Pilocarpine Nitrate-028 | 144461-11-0 | [(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde |
| Pilocarpine Nitrate-013 | 74-89-5 | Methylamine |
| Pilocarpine Nitrate-029 | - | (4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one |
| Pilocarpine Nitrate-030 | 38993-98-5 | (3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one |
Frequently asked questions
What are the approved indications of Pilocarpine Hydrochloride?
Approved indications include: 闭角型青光眼, Ocular hypertension, Open-angle glaucoma, 瞳孔缩小, Sjögren's syndrome, 虹膜炎, 口腔干燥, Glaucoma.
When does the Pilocarpine Hydrochloride patent expire?
No public expiry year is available for Pilocarpine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Pilocarpine Hydrochloride?
5 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pilocarpine Hydrochloride intermediates?
1 intermediate CAS of Pilocarpine Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pilocarpine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27