利非司特
Tier C — Watch / tradeLifitegrast
Targets：ITGAL&ITGB2
Brand：朗悦明、Xiidra
Indications (approved)：干眼症、干眼综合征
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| LIFI-001 | 82311-69-1Available | (S)-2-amino-3-(3-bromophenyl)propanoic acid |
| LIFI-002 | 82278-73-7Available | (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid |
| LIFI-003 | 1289646-76-9Available | (S)-2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoic acid |
| LIFI-004 | 1289646-78-1Available | (S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoate |
| LIFI-005 | 1194550-59-8Available | (S)-benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride |
| LIFI-006 | 1194550-56-5Available | 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid |
| LIFI-007 | 1194550-63-4Available | (S)-benzyl 2-(5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate |
| LIFI-008 | 1194550-65-6Available | (S)-benzyl 2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride |
| LIFI-009 | 77095-51-3Available | benzofuran-6-carboxylic acid |
| LIFI-010 | 1194550-67-8Available | (S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate |
| LIFI-011 | 10203-08-4Available | 3,5-dichlorobenzaldehyde |
| LIFI-012 | 1011513-99-7Available | 2-chloroethan-1-amine hydrochloride |
| LIFI-013 | 14046-41-4Available | 2-chloro-N-(3,5-dichlorobenzyl)ethanamine |
| LIFI-014 | 89315-56-0Available | 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline |
| LIFI-015 | 1289646-72-5Available | 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline |
| LIFI-016 | 6272-26-0Available | 6-hydroxybenzofuran-3(2H)-one |
| LIFI-017 | 299912-77-9Available | 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one |
| LIFI-018 | 13196-11-7Available | benzofuran-6-ol |
| LIFI-019 | 227752-25-2Available | benzofuran-6-yl trifluoromethanesulfonate |
| LIFI-020 | 588703-29-1Available | methyl benzofuran-6-carboxylate |
Frequently asked questions
What are the approved indications of Lifitegrast?
Approved indications include: 干眼症, 干眼综合征.
When does the Lifitegrast patent expire?
No public expiry year is available for Lifitegrast yet; this page updates once verified.
How many synthesis routes are recorded for Lifitegrast?
1 synthesis routes are recorded; the shortest is 18 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Lifitegrast intermediates?
20 intermediate CAS of Lifitegrast are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Lifitegrast intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24