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CAS 77095-51-3
benzofuran-6-carboxylic acid
Codes：LIFI-009
Application context (from source-drug indications)
干眼症利非司特干眼综合征利非司特移植物抗宿主病利非司特糖尿病黄斑水肿利非司特干燥性角结膜炎利非司特变应性结膜炎利非司特
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 利非司特Lifitegrast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-amino-3-(3-bromophenyl)propanoic acid→(S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid→(S)-2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoic acid→(S)-benzyl 2-((tert-butoxycarbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoate→(S)-benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride→5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid→(S)-benzyl 2-(5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate→(S)-benzyl 2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride→benzofuran-6-carboxylic acid→(S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate→3,5-dichlorobenzaldehyde→2-chloroethan-1-amine hydrochloride→2-chloro-N-(3,5-dichlorobenzyl)ethanamine→5,7-dichloro-1,2,3,4-tetrahydroisoquinoline→5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline→6-hydroxybenzofuran-3(2H)-one→6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one→benzofuran-6-ol→benzofuran-6-yl trifluoromethanesulfonate→methyl benzofuran-6-carboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | benzofuran-6-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.