Unibest 优贝德
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CAS 10203-08-4

3,5-Dichlorobenzaldehyde3,5-dichlorobenzaldehyde

Codes:(Ia)409139-7-a、LIFI-011、(II)409139-8-a

Application context (from source-drug indications)

转甲状腺素运载蛋白淀粉样变性氯苯唑酸心脏病氯苯唑酸干眼症利非司特干眼综合征利非司特移植物抗宿主病利非司特糖尿病黄斑水肿利非司特干燥性角结膜炎利非司特变应性结膜炎利非司特淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺

Source drugs (routes using this intermediate)

DrugTierExpiry
氯苯唑酸TafamidisTier C — Watch / trade-
利非司特LifitegrastTier C — Watch / trade-
氯苯唑酸葡甲胺Tafamidis MeglumineTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

氯苯唑酸葡甲胺优化路线steps: 1total yield: /
2-Hydroxy-4-methoxycarbonylaniline→Butyl 4-amino-3-hydroxybenzoate→tert-Butyl 4-amino-3-hydroxybenzoate→Phenyl 4-amino-3-hydroxybenzoate→3,5-Dichlorobenzaldehyde→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→tert-Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→Phenyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate

Intermediates available on this site

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SupplierProductPrice bandMOQLead timeQualifications
Unibest Nantong cGMP Sitebenzofuran-6-carboxylic acid
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Unibest Taizhou GMP-like Site2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
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Qualified Partner — East China API Works5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
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Unibest Nantong cGMP Sitemethyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
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