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Diquafosol Tetrasodium

Santen Pharmaceutical Co Ltd

Originator

2010

First approval

Expiry (public)

$0.16B ▲

Peak sales

化学药

Type

Targets：P2RY2

Brand：Prolacria、Diquas

Indications (approved)：干眼症

Regional status

China

批准上市

2017-10-20

Japan

批准上市

2010-04-16

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 1 · Total yield /

Code	CAS No.	Intermediate
DIQU-001	58-97-9	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

OptimisedRoute 2Steps 2 · Total yield /

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
DIQU-002	58-98-0	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate
DIQU-003	288-32-4	1H-imidazole
DIQU-004	214403-86-8	(1H-imidazol-1-yl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride

OptimisedRoute 3Steps 2 · Total yield /

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
DIQU-001	58-97-9	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
DIQU-005	63-39-8	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen triphosphate
DIQU-006	92929-68-5	6-(((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)-1,3,5,2,4,6-trioxatriphosphinane-2,4-bis(olate) 2,4,6-trioxide

OptimisedRoute 4Steps 2 · Total yield /

Synthetic routes & intermediates Route 4

Code	CAS No.	Intermediate
DIQU-001	58-97-9	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
DIQU-007	7758-16-9	sodium dihydrogen diphosphate(2:1)
DIQU-008	2466-09-3	diphosphoric acid

OptimisedRoute 5Steps 2 · Total yield /

Synthetic routes & intermediates Route 5

Code	CAS No.	Intermediate
DIQU-002	58-98-0	((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate
DIQU-009	-	-
DIQU-010	-	-

Frequently asked questions

What are the approved indications of Diquafosol Tetrasodium?

Approved indications include: 干眼症.

When does the Diquafosol Tetrasodium patent expire?

No public expiry year is available for Diquafosol Tetrasodium yet; this page updates once verified.

How many synthesis routes are recorded for Diquafosol Tetrasodium?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Diquafosol Tetrasodium intermediates?

All intermediates in Diquafosol Tetrasodium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Diquafosol Tetrasodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24