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CAS 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine
Codes：VENE-001、VEMF-007
Application context (from source-drug indications)
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Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-1H-pyrrolo[2,3-b]pyridine→5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol→methyl 2,4-difluorobenzoate→methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate→1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine→methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate→5-bromo-1H-pyrrolo[2,3-b]pyridine→5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→methyl 4,4-dimethyl-2-oxocyclohexane-1-carboxylate→methyl 4,4-dimethyl-2-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene-1-carboxylate→(4-chlorophenyl)boronic acid→methyl 4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate→(4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol→tert-butyl piperazine-1-carboxylate→tert-butyl 4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine-1-carboxylate
2,4-difluoroaniline→benzyl 3-amino-2,6-difluorobenzoate→propane-1-sulfonyl chloride→benzyl 2,6-difluoro-3-(propylsulfonamido)benzoate→2,6-difluoro-3-(propylsulfonamido)benzoic acid→2,6-difluoro-3-(propylsulfonamido)benzoyl chloride→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid
2,6-difluoro-3-(propylsulfonamido)benzoic acid→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-bromo-3-iodopyridin-2-amine→2,6-dichlorobenzoyl chloride→N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
propane-1-sulfonyl chloride→5-bromo-1H-pyrrolo[2,3-b]pyridine→(4-chlorophenyl)boronic acid→2,6-dichlorobenzoyl chloride→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→2,6-difluoro-3-nitrobenzoyl chloride→(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-difluoro-3-nitrophenyl)methanone→(3-amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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