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考比司他
Tier C — Watch / tradeCobicistat
Gilead Sciences Inc
Originator
2013
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：CYP3A
Brand：Tybost
Indications (approved)：HIV感染
Regional status
US
撤市
EU
批准上市
2013-09-19
China
-
Japan
-
Synthetic routes & intermediates3 routes
Originator routes × 1Optimised (non-patent) × 2Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield 580 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-001 | 154212-60-9 | 1-(2-isopropylthiazol-4-yl)-N-methylmethanamine |
| COBI-002 | 3350-15-0 | (S)-methyl 2-amino-4-((tert-butoxycarbonyl)amino)butanoate hydrochloride |
| COBI-003 | 1004316-83-9 | (S)-methyl 4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate |
| COBI-004 | 1004316-84-0 | (S)-4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoic acid |
| COBI-005 | 1004316-18-0 | thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate |
| COBI-006 | 1004316-85-1 | - |
| COBI-007 | 1004316-87-3 | thiazol-5-ylmethyl ((2R,5R)-5-((S)-4-amino-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate |
| COBI-008 | 108385-55-3 | (S)-tert-butyl (1-phenyl-3-(phenylsulfonyl)propan-2-yl)carbamate |
| COBI-009 | 158380-76-8 | (S)-tert-butyl benzyl(1-oxo-3-phenylpropan-2-yl)carbamate |
| COBI-010 | 1004316-38-4 | tert-butyl benzyl((2S,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-1,6-diphenyl-4-(phenylsulfonyl)hexan-2-yl)carbamate |
| COBI-011 | 168846-63-7 | tert-butyl benzyl((2S,5S,E)-5-((tert-butoxycarbonyl)amino)-1,6-diphenylhex-3-en-2-yl)carbamate |
| COBI-012 | 168846-62-6 | di-tert-butyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate |
| COBI-013 | 144186-34-5 | (2R,5R)-1,6-diphenylhexane-2,5-diamine |
| COBI-014 | 144163-97-3 | 4-nitrophenyl (thiazol-5-ylmethyl) carbonate |
OptimisedRoute 2Steps 11 · Total yield 15.95 g
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-001 | 154212-60-9 | 1-(2-isopropylthiazol-4-yl)-N-methylmethanamine |
| COBI-005 | 1004316-18-0 | thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate |
| COBI-013 | 144186-34-5 | (2R,5R)-1,6-diphenylhexane-2,5-diamine |
| COBI-014 | 144163-97-3 | 4-nitrophenyl (thiazol-5-ylmethyl) carbonate |
| COBI-015 | 6372-14-1 | (S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate |
| COBI-016 | 137649-69-5 | dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate |
| COBI-017 | 6160-65-2 | di(1H-imidazol-1-yl)methanethione |
| COBI-018 | 1004316-58-8 | dibenzyl ((1S,1'S)-((4R,5R)-2-thioxo-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate |
| COBI-019 | 144163-56-4 | dibenzyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate |
| COBI-020 | 1004316-92-0 | (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoic acid |
| COBI-021 | 1423796-11-5 | (S)-3-aminodihydrofuran-2(3H)-one hydrobromide |
| COBI-022 | 1004316-93-1 | (S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)urea |
| COBI-023 | - | (S)-benzyl 4-hydroxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate |
| COBI-024 | 1004316-95-3 | (S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutanoate |
| COBI-025 | 110-91-8Available | morpholine |
| COBI-026 | 1004316-96-4 | (S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate |
OptimisedRoute 3Steps 12 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-001 | 154212-60-9 | 1-(2-isopropylthiazol-4-yl)-N-methylmethanamine |
| COBI-013 | 144186-34-5 | (2R,5R)-1,6-diphenylhexane-2,5-diamine |
| COBI-014 | 144163-97-3 | 4-nitrophenyl (thiazol-5-ylmethyl) carbonate |
| COBI-021 | 1423796-11-5 | (S)-3-aminodihydrofuran-2(3H)-one hydrobromide |
| COBI-022 | 1004316-93-1 | (S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)urea |
| COBI-025 | 110-91-8Available | morpholine |
| COBI-027 | 73058-30-7 | (S)-2-benzylaziridine |
| COBI-028 | 13360-57-1 | dimethylsulfamoyl chloride |
| COBI-029 | 902146-43-4 | (S)-2-benzyl-N,N-dimethylaziridine-1-sulfonamide |
| COBI-030 | 1247119-27-2 | - |
| COBI-031 | 144163-57-5 | (2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diamine |
| COBI-032 | 1247119-31-8 | (2R,5R)-1,6-diphenylhexane-2,5-diamine dihydrochloride |
| COBI-033 | 1247119-33-0 | thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate hydrochloride |
| COBI-034 | 1169870-16-9 | potassium (S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate |
| COBI-035 | 63-68-3 | (S)-2-amino-4-(methylthio)butanoic acid |
| COBI-036 | 1051461-77-8 | (S)-ethyl 4-iodo-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate |
| COBI-037 | 1247119-36-3 | (S)-ethyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate |
Frequently asked questions
What are the approved indications of Cobicistat?
Approved indications include: HIV感染.
When does the Cobicistat patent expire?
No public expiry year is available for Cobicistat yet; this page updates once verified.
How many synthesis routes are recorded for Cobicistat?
3 synthesis routes are recorded; the shortest is 10 steps with 580 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cobicistat intermediates?
1 intermediate CAS of Cobicistat are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Cobicistat intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24