← Back to patent-cliff list
CAS 1004316-18-0
thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate
Codes：COBI-005
Application context (from source-drug indications)
HIV感染考比司他非小细胞肺癌考比司他获得性免疫缺损综合征考比司他
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 考比司他Cobicistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→(S)-methyl 2-amino-4-((tert-butoxycarbonyl)amino)butanoate hydrochloride→(S)-methyl 4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoic acid→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate→COBI-006→thiazol-5-ylmethyl ((2R,5R)-5-((S)-4-amino-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate→(S)-tert-butyl (1-phenyl-3-(phenylsulfonyl)propan-2-yl)carbamate→(S)-tert-butyl benzyl(1-oxo-3-phenylpropan-2-yl)carbamate→tert-butyl benzyl((2S,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-1,6-diphenyl-4-(phenylsulfonyl)hexan-2-yl)carbamate→tert-butyl benzyl((2S,5S,E)-5-((tert-butoxycarbonyl)amino)-1,6-diphenylhex-3-en-2-yl)carbamate→di-tert-butyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→di(1H-imidazol-1-yl)methanethione→dibenzyl ((1S,1'S)-((4R,5R)-2-thioxo-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoic acid→(S)-3-aminodihydrofuran-2(3H)-one hydrobromide→(S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)urea→(S)-benzyl 4-hydroxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-oxobutanoate→morpholine→(S)-benzyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.