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CAS 1004316-87-3
thiazol-5-ylmethyl ((2R,5R)-5-((S)-4-amino-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate
Codes：COBI-007
Application context (from source-drug indications)
HIV感染考比司他非小细胞肺癌考比司他获得性免疫缺损综合征考比司他
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 考比司他Cobicistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→(S)-methyl 2-amino-4-((tert-butoxycarbonyl)amino)butanoate hydrochloride→(S)-methyl 4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoic acid→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate→COBI-006→thiazol-5-ylmethyl ((2R,5R)-5-((S)-4-amino-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate→(S)-tert-butyl (1-phenyl-3-(phenylsulfonyl)propan-2-yl)carbamate→(S)-tert-butyl benzyl(1-oxo-3-phenylpropan-2-yl)carbamate→tert-butyl benzyl((2S,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-1,6-diphenyl-4-(phenylsulfonyl)hexan-2-yl)carbamate→tert-butyl benzyl((2S,5S,E)-5-((tert-butoxycarbonyl)amino)-1,6-diphenylhex-3-en-2-yl)carbamate→di-tert-butyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate
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