恩格列净
Tier A — Act nowEmpagliflozin · all drugs expiring in 2028 →
Targets：SGLT2
Brand：Jardiance、Gibtulio、Oboravo、欧唐静
Indications (approved)：慢性肾功能不全、心脏衰竭、二型糖尿病
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| EMPA-001 | 21739-92-4Available | 5-bromo-2-chlorobenzoic acid |
| EMPA-002 | 100-66-3Available | anisole |
| EMPA-003 | 333361-49-2Available | (5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone |
| EMPA-004 | 333361-51-6Available | 4-bromo-1-chloro-2-(4-methoxybenzyl)benzene |
| EMPA-005 | 864070-18-8Available | 4-(5-bromo-2-chlorobenzyl)phenol |
| EMPA-006 | 864070-19-9Available | (4-(5-bromo-2-chlorobenzyl)phenoxy)(tert-butyl)dimethylsilane |
| EMPA-007 | 32384-65-9Available | (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one |
| EMPA-008 | 1204220-63-2Available | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
| EMPA-009 | 864070-37-1Available | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| EMPA-010 | 219823-47-9Available | (R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate |
| EMPA-011 | 90-80-2Available | (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| EMPA-007 | 32384-65-9Available | (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one |
| EMPA-020 | 189628-37-3Available | (S)-3-(4-bromophenoxy)tetrahydrofuran |
| EMPA-021 | 857854-82-1Available | 5-bromo-2-chlorobenzaldehyde |
| EMPA-022 | 1800196-43-3Available | (5-bromo-2-chlorophenyl)(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methanol |
| EMPA-023 | 1800196-44-4Available | ((5-bromo-2-chlorophenyl)(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methoxy)trimethylsilane |
| EMPA-024 | - | (2S,3R,4S,5R,6R)-2-(4-chloro-3-((4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)((trimethylsilyl)oxy)methyl)phenyl)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-ol |
| EMPA-025 | 1800196-50-2Available | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(methoxy(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
| Code | CAS No. | Intermediate |
|---|---|---|
| EMPA-007 | 32384-65-9Available | (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one |
| EMPA-012 | 19094-56-5Available | 2-chloro-5-iodobenzoic acid |
| EMPA-013 | 462-06-6Available | fluorobenzene |
| EMPA-014 | 915095-86-2Available | (2-chloro-5-iodophenyl)(4-fluorophenyl)methanone |
| EMPA-015 | 86087-23-2Available | (S)-tetrahydrofuran-3-ol |
| EMPA-016 | 915095-87-3Available | (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone |
| EMPA-017 | 915095-94-2Available | (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)tetrahydrofuran |
| EMPA-018 | 1637561-74-0Available | (2S,3R,4S,5R,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-ol |
| EMPA-019 | 1279691-36-9Available | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
Frequently asked questions
What are the approved indications of Empagliflozin?
Approved indications include: 慢性肾功能不全, 心脏衰竭, 二型糖尿病.
When does the Empagliflozin patent expire?
Based on public sources, the Empagliflozin patent expires in 2028.
How many synthesis routes are recorded for Empagliflozin?
3 synthesis routes are recorded; the shortest is 5 steps with 0.2 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Empagliflozin intermediates?
24 intermediate CAS of Empagliflozin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Empagliflozin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24