Drugs Losing Exclusivity in 2028 & Key Intermediates
18 drugs expire in 2028 (public sources), 18 with recorded synthesis routes; key intermediates of 12 drugs are already available through the Unibest supply network. Generic developers typically secure intermediate supply 2–3 years ahead — use this table for shortlisting and RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| 枸橼酸托法替布 Tofacitinib Citrate | B · Position early | 2028 | 强直性脊柱炎、幼年型类风湿性关节炎、溃疡性结肠炎 | 7 | 34 | Available ×34 |
| 罗沙司他 Roxadustat | C · Watch | 2028 | 贫血 | 3 | 33 | Available ×33 |
| 阿哌沙班 Apixaban | A · Act now | 2028 | 肺栓塞、静脉血栓形成、Paget-Schroetter综合征 | 7 | 30 | Available ×30 |
| 布瓦西坦 Brivaracetam | C · Watch | 2028 | 癫痫部分性发作、癫痫、癫痫发作 | 3 | 26 | Available ×26 |
| 恩格列净 Empagliflozin | A · Act now | 2028 | 慢性肾功能不全、心脏衰竭、二型糖尿病 | 3 | 24 | Available ×24 |
| 磷酸芦可替尼 Ruxolitinib Phosphate | A · Act now | 2028 | 特应性皮炎、白癜风、移植物抗宿主病 | 4 | 24 | Available ×24 |
| 甲磺酸仑伐替尼 Lenvatinib Mesilate | A · Act now | 2028 | 肾细胞癌、子宫内膜癌、肝细胞癌 | 3 | 18 | Available ×18 |
| 奥拉帕利 Olaparib | A · Act now | 2028 | 子宫内膜癌、去势抵抗性前列腺肿瘤、前列腺癌 | 2 | 13 | Available ×13 |
| 盐酸鲁拉西酮 Lurasidone Hydrochloride | B · Position early | 2028 | 重度抑郁症、精神分裂症、躁狂症 | 6 | 20 | Available ×4 |
| 甲苯磺酸艾多沙班 Edoxaban Tosilate Hydrate | B · Position early | 2028 | 肺栓塞、静脉血栓栓塞、中风 | 6 | 37 | Available ×3 |
| 拉考沙胺 Lacosamide | B · Position early | 2028 | 强直阵挛性癫痫、癫痫、癫痫部分性发作 | 7 | 35 | Available ×3 |
| 阿伐那非 Avanafil | C · Watch | 2028 | 勃起功能障碍 | 7 | 35 | Available ×3 |
| 阿普米司特 Apremilast | B · Position early | 2028 | 斑块银屑病、白塞病综合征、口腔溃疡 | 6 | 25 | - |
| 舒更葡糖钠 Sugammadex Sodium | B · Position early | 2028 | 神经肌肉阻滞 | 1 | - | - |
| 托伐普坦 Tolvaptan | B · Position early | 2028 | 常染色体显性多囊肾病、纤维化、低钠血症 | 6 | 28 | - |
| 贝曲沙班 Betrixaban | C · Watch | 2028 | 静脉血栓栓塞、肝功能衰退、心房颤动 | 2 | 10 | - |
| 吡仑帕奈 Perampanel Hydrate | C · Watch | 2028 | 强直阵挛性癫痫、癫痫部分性发作、癫痫 | 5 | 34 | - |
| 非达霉素 Fidaxomicin | C · Watch | 2028 | 艰难梭菌感染、肠炎、腹泻 | 1 | - | - |
Frequently asked questions
Which drugs lose exclusivity in 2028?
18 drugs expire in 2028 per public sources: Apixaban, Empagliflozin, Tofacitinib Citrate, Apremilast, Ruxolitinib Phosphate, Olaparib, etc.
When should we start sourcing intermediates for 2028 launches?
Generic developers typically secure development-scale supply 2–3 years before expiry. 12 of the 18 drugs in this table already have on-sale intermediates in the Unibest network; the rest can be RFQ'd per CAS.
Are route and CAS data verified?
All fields are structured data cross-verified from public sources; intermediates carry registry codes and CAS numbers, and every "Available" badge links to real listings.
Source: cross-verified structured fields · Expiry years are public-source estimates; consult individual agencies for authoritative dates · 2026-09-24