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CAS 86087-23-2
(S)-tetrahydrofuran-3-ol
Codes：EMPA-015、AFAT-006
Application context (from source-drug indications)
慢性肾功能不全恩格列净心脏衰竭恩格列净二型糖尿病恩格列净非小细胞肺癌马来酸阿法替尼头颈部鳞状细胞癌马来酸阿法替尼头颈癌马来酸阿法替尼脊索瘤马来酸阿法替尼鳞状细胞癌马来酸阿法替尼胆囊癌马来酸阿法替尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→2-chloro-5-iodobenzoic acid→fluorobenzene→(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone→(S)-tetrahydrofuran-3-ol→(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone→(S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)tetrahydrofuran→(2S,3R,4S,5R,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-ol→(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
2-amino-4-fluoro-5-nitrobenzoic acid→N-(4-((3-chloro-4-fluorophenyl)(3,4-dimethoxybenzyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide→3-chloro-N-(3,4-dimethoxybenzyl)-4-fluoroaniline→3-chloro-4-fluoroaniline→N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→(E)-4-bromobut-2-enoic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→2-amino-4-chlorobenzoic acid→7-chloroquinazolin-4(3H)-one→7-chloro-6-nitroquinazolin-4(4aH)-one→4,7-dichloro-6-nitroquinazoline→N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine→2-(diethoxyphosphoryl)acetic acid→(S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate→2,2-diethoxy-N,N-dimethylethanamine→maleic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→methyl 3-amino-4-hydroxybenzoate→methyl 5-amino-4-hydroxy-2-nitrobenzoate→methyl 2,5-diamino-4-hydroxybenzoate→6-amino-7-hydroxyquinazolin-4(3H)-one→6-amino-4-chloroquinazolin-7-ol→(S)-4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-amine→(E)-4-(dimethylamino)but-2-enoyl chloride→(S,E)-N-(4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(E)-4-(dimethylamino)but-2-enoyl chloride→4-hydroxybenzonitrile→4-hydroxy-3-nitrobenzonitrile→(S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | (S)-(+)-3-Hydroxytetrahydrofuran Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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