普托马尼
Tier C — Watch / tradePretomanid
Targets：DNA
Brand：Pretomanid FGK
Indications (approved)：结核分枝杆菌感染、耐多药肺结核
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PRET-001 | 5213-49-0 | 2,4-dinitro-1H-imidazole |
| PRET-002 | 123237-62-7 | (S)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane |
| PRET-003 | 187235-04-7 | (S)-1-((tert-butyldimethylsilyl)oxy)-3-(2,4-dinitro-1H-imidazol-1-yl)propan-2-ol |
| PRET-004 | 187235-73-0 | 1-((2S)-3-((tert-butyldimethylsilyl)oxy)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-2,4-dinitro-1H-imidazole |
| PRET-005 | 187235-06-9 | (6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine |
| PRET-006 | 187235-08-1 | (S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol |
| PRET-007 | 50824-05-0 | 1-(bromomethyl)-4-(trifluoromethoxy)benzene |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRET-001 | 5213-49-0 | 2,4-dinitro-1H-imidazole |
| PRET-005 | 187235-06-9 | (6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine |
| PRET-006 | 187235-08-1 | (S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol |
| PRET-007 | 50824-05-0 | 1-(bromomethyl)-4-(trifluoromethoxy)benzene |
| PRET-008 | 288-32-4 | 1H-imidazole |
| PRET-009 | 3034-38-6 | 4-nitro-1H-imidazole |
| PRET-010 | 19182-81-1 | 1,4-dinitro-1H-imidazole |
| PRET-011 | 65031-96-1 | (S)-oxiran-2-ylmethyl butyrate |
| PRET-012 | 1258937-18-6 | (S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-hydroxypropyl butyrate |
| PRET-013 | 1258937-19-7 | (2S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl butyrate |
Frequently asked questions
What are the approved indications of Pretomanid?
Approved indications include: 结核分枝杆菌感染, 耐多药肺结核.
When does the Pretomanid patent expire?
No public expiry year is available for Pretomanid yet; this page updates once verified.
How many synthesis routes are recorded for Pretomanid?
2 synthesis routes are recorded; the shortest is 5 steps with 0.49 g (Pretomanid) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pretomanid intermediates?
All intermediates in Pretomanid routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Pretomanid intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24