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CAS 187235-08-1
(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol
Codes：PRET-006
Application context (from source-drug indications)
结核分枝杆菌感染普托马尼耐多药肺结核普托马尼肺结核普托马尼广泛耐药结核普托马尼肾功能不全普托马尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 普托马尼Pretomanid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,4-dinitro-1H-imidazole→(S)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane→(S)-1-((tert-butyldimethylsilyl)oxy)-3-(2,4-dinitro-1H-imidazol-1-yl)propan-2-ol→1-((2S)-3-((tert-butyldimethylsilyl)oxy)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-2,4-dinitro-1H-imidazole→(6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine→(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol→1-(bromomethyl)-4-(trifluoromethoxy)benzene
2,4-dinitro-1H-imidazole→(6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine→(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol→1-(bromomethyl)-4-(trifluoromethoxy)benzene→1H-imidazole→4-nitro-1H-imidazole→1,4-dinitro-1H-imidazole→(S)-oxiran-2-ylmethyl butyrate→(S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-hydroxypropyl butyrate→(2S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl butyrate
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