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CAS 109-77-3
1,1-Dicyanomethane
Codes：(II)461018-3-a、(IV)461018-4-a、(II)461018-22-a、(VII)461018-25-a、(I)461018-27-a
Application context (from source-drug indications)
华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 伊布替尼Ibrutinib | Tier A — Act now | 2027 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→(4-Phenoxybenzoyl)malononitrile→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one→1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→(Dimethylamino)formaldehyde dimethyl acetal
4-(Phenyloxy)benzoic acid→Carbonochloridic acid ethyl ester→Ethyl 4-phenoxybenzoyl carbonate→1,1-Dicyanomethane→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(4-Phenoxybenzoyl)malononitrile→[Chloro(4-phenoxyphenyl)methylene]malononitrile→3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→Formamidine acetate→3-Chloro-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-ylmethanesulfonate
4-Phenoxybenzaldehyde→1,1-Dicyanomethane→[(4-Phenoxyphenyl)methylidene]propanedinitrile→Hydrazine hydrate→4-Methylbenzenesulfonhydrazide→5-Amino-3-(4-phenoxyphenyl)-2,3-dihydro-1H-pyrazole-4-carbonitrile→3-(4-Phenoxyphenyl)-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→4-Methyl-N'-[(4-phenoxyphenyl)methyl]benzene-1-sulfonohydrazide→Amide c1
(3R)-3-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)(nitroso)amino]piperidine-1-carboxylate→tert-Butyl (3R)-3-[1-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate→(3R)-3-Hydrazinylpiperidine→Amide c1→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→5-Amino-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carbonitrile→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbaldehyde→2-Propenoyl chloride→3-Aminopiperidine→5-Oxo-D-proline (3R)-piperidin-3-amine→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate
1,1-Dicyanomethane→(Diethoxymethoxy)ethane→(Ethoxymethylene)malononitrile→N-Boc-3(R)-hydrazinylpiperidine→(4-Phenoxyphenyl)boranediol→tert-Butyl (3R)-3-(5-amino-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate→Amide c1→tert-Butyl (3R)-3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-(1H-Imidazol-1-yl)prop-2-en-1-one→5-Chloro-1-[(prop-2-enoyl)oxy]-1H-benzotriazole
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