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CAS 127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole
Codes：EFIN-009
Application context (from source-drug indications)
甲癣艾氟康唑
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 艾氟康唑Efinaconazole | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (R)-2-hydroxypropanoate→(R)-2-hydroxy-1-morpholinopropan-1-one→3,4-dihydro-2H-pyran→(2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→(2,4-difluorophenyl)magnesium bromide→(2R)-1-(2,4-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→1H-1,2,4-triazole→(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate→1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole→4-methylenepiperidine hydrobromide
1H-1,2,4-triazole→1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole→2-chloro-1-(2,4-difluorophenyl)ethan-1-one→trimethylsilanecarbonitrile→(((2S,3S,4R)-4-(4,5-difluoro-2-hydroxyphenoxy)-3-hydroxytetrahydro-2H-pyran-2-yl)methyl)diphenylphosphine oxide→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile→(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal→(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol→4-methylenepiperidine
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