← Back to patent-cliff list
CAS 135270-08-5
(2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one
Codes：ISAV-003、EFIN-004
Application context (from source-drug indications)
毛霉菌目感染硫酸艾沙康唑曲霉菌属感染硫酸艾沙康唑隐孢子虫感染硫酸艾沙康唑真菌感染硫酸艾沙康唑甲癣艾氟康唑
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (R)-2-hydroxypropanoate→(R)-2-hydroxy-1-morpholinopropan-1-one→(2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→2-bromo-1,4-difluorobenzene→(2R)-1-(2,5-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→2-((1R)-1-(2-(2,5-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran→1H-1,2,4-triazole→(3R)-2-(2,5-difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol→(2R,3R)-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol→1-(((2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole→(2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile→(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide→4-(2-bromoacetyl)benzonitrile→4-(2-((2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile→(2-(((1-chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate→4-(1-(((3-((2-((tert-butoxycarbonyl)(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium chloride→2-chloronicotinic acid→2-chloronicotinoyl chloride→tert-butyl 2-chloronicotinate→tert-butyl 2-(methylamino)nicotinate→(2-(methylamino)pyridin-3-yl)methanol→1-chloroethyl carbonochloridate
methyl (R)-2-hydroxypropanoate→(R)-2-hydroxy-1-morpholinopropan-1-one→3,4-dihydro-2H-pyran→(2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→(2,4-difluorophenyl)magnesium bromide→(2R)-1-(2,4-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one→1H-1,2,4-triazole→(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate→1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole→4-methylenepiperidine hydrobromide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 4-(2-Bromoacetyl)benzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | (2-(((1-Chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.