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CAS 127168-78-9
1-(8-methoxy-4-(o-tolylamino)quinolin-3-yl)butan-1-one
Codes：DANOP-007
Application context (from source-drug indications)
丙型肝炎达诺瑞韦钠慢性丙型肝炎达诺瑞韦钠病毒感染达诺瑞韦钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 达诺瑞韦钠Danoprevir Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride→1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→(2S,4R)-tert-butyl 2-(((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl)carbamoyl)-4-hydroxypyrrolidine-1-carboxylate→(S)-2-((tert-butoxycarbonyl)amino)non-8-enoic acid→(1R,2S)-ethyl 1-((2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-hydroxy-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→1-(8-methoxy-4-(o-tolylamino)quinolin-3-yl)butan-1-one→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→(2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylic acid→cyclopropanesulfonamide
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