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CAS 74844-91-0
1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
Codes：DANOP-002、GRAZ-037
Application context (from source-drug indications)
丙型肝炎达诺瑞韦钠慢性丙型肝炎达诺瑞韦钠病毒感染达诺瑞韦钠丙型肝炎Grazoprevir HydrateHIV感染Grazoprevir Hydrate慢性丙型肝炎Grazoprevir Hydrate肾功能不全Grazoprevir Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 达诺瑞韦钠Danoprevir Sodium | Tier C — Watch / trade | - |
| Grazoprevir HydrateGrazoprevir Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride→1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→(2S,4R)-tert-butyl 2-(((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropyl)carbamoyl)-4-hydroxypyrrolidine-1-carboxylate→(S)-2-((tert-butoxycarbonyl)amino)non-8-enoic acid→(1R,2S)-ethyl 1-((2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-hydroxy-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→1-(8-methoxy-4-(o-tolylamino)quinolin-3-yl)butan-1-one→(2R,6S,13aS,14aR,16aS,Z)-ethyl 6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate→(2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-2-((4-fluoroisoindoline-2-carbonyl)oxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylic acid→cyclopropanesulfonamide
diethyl oxalate→methyl (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-13-ene-35-carboxylate→methyl (33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylate→but-3-en-1-ylmagnesium bromide→(1R,2R)-2-(pent-2-yn-1-yl)cyclopropan-1-ol→(R)-3,3-dimethyl-2-((((1R,2R)-2-(pent-2-yn-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→ethyl 2-oxohex-5-enoate→4-methoxybenzene-1,2-diamine→3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-ol→2-(but-3-en-1-yl)-3-chloro-6-methoxyquinoxaline→1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate→methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate→(S)-3,3-dimethyl-2-((((1R,2R)-2-((Z)-pent-2-en-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-((Z)-pent-2-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate→GRAZ-042
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