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CAS 1396893-39-2
1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one
Codes：ALPE-014
Application context (from source-drug indications)
生长障碍阿吡利塞遗传病阿吡利塞PIK3CA相关生长过度谱系阿吡利塞乳腺癌阿吡利塞
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿吡利塞Alpelisib | Tier C — Watch / trade | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine→(S)-pyrrolidine-2-carboxamide→4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine→N-methoxy-N-methylacetamide→1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one→1-bromopyrrolidine-2,5-dione→4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine hydrobromide→phenyl (4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)carbamate
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