阿吡利塞
Tier C — Watch / tradeAlpelisib · all drugs expiring in 2029 →
Targets：PI3Kα
Brand：Piqray、Vijoice
Indications (approved)：生长障碍、遗传病、PIK3CA相关生长过度谱系、乳腺癌
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ALPE-001 | 889940-13-0 | 3,3,3-trifluoro-2,2-dimethylpropanoic acid |
| ALPE-002 | 1163707-53-6 | 3,3,3-trifluoro-2,2-dimethylpropanoyl chloride |
| ALPE-003 | 4652-27-1 | ethyl 3-oxo-3-((3-(trifluoromethyl)phenyl)amino)propanoate |
| ALPE-004 | 1357476-64-2 | 2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4H-pyran-4-one |
| ALPE-005 | 1357476-66-4 | 2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4(1H)-one |
| ALPE-006 | 1357476-67-5 | 4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine |
| ALPE-007 | 7336-51-8 | N-(4-methylthiazol-2-yl)acetamide |
| ALPE-008 | 1357476-68-6 | N-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)acetamide |
| ALPE-009 | 1357476-69-7 | 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine |
| ALPE-010 | 1357476-70-0 | N-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-imidazole-1-carboxamide |
| ALPE-011 | 7531-52-4 | (S)-pyrrolidine-2-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| ALPE-009 | 1357476-69-7 | 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine |
| ALPE-011 | 7531-52-4 | (S)-pyrrolidine-2-carboxamide |
| ALPE-012 | 1378865-93-0 | 4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine |
| ALPE-013 | 78191-00-1 | N-methoxy-N-methylacetamide |
| ALPE-014 | 1396893-39-2 | 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one |
| ALPE-015 | 128-08-5Available | 1-bromopyrrolidine-2,5-dione |
| ALPE-016 | 1396893-40-5 | 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine hydrobromide |
| ALPE-017 | 1396893-41-6 | phenyl (4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)carbamate |
Frequently asked questions
What are the approved indications of Alpelisib?
Approved indications include: 生长障碍, 遗传病, PIK3CA相关生长过度谱系, 乳腺癌.
When does the Alpelisib patent expire?
Based on public sources, the Alpelisib patent expires in 2029.
How many synthesis routes are recorded for Alpelisib?
2 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Alpelisib intermediates?
1 intermediate CAS of Alpelisib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Alpelisib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24