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CAS 1403831-79-7
(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide
Codes：NERT-021
Application context (from source-drug indications)
乳腺癌马来酸奈拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马来酸奈拉替尼Neratinib Maleate | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-chloro-4-(pyridin-2-ylmethoxy)aniline→(E)-but-2-enoyl chloride→methyl 3-amino-4-ethoxybenzoate→(E)-methyl 3-(but-2-enamido)-4-ethoxybenzoate→(E)-methyl 5-(but-2-enamido)-4-ethoxy-2-nitrobenzoate→NERT-017→3,3-diethoxypropanenitrile→methyl 5-((E)-but-2-enamido)-2-((2-cyanovinyl)amino)-4-ethoxybenzoate→(E)-N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)but-2-enamide→(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide→(E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide→(E)-4-bromo-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide
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