CAS 524955-09-7

3-chloro-4-(pyridin-2-ylmethoxy)aniline

Codes：NERT-005

Application context (from source-drug indications)

乳腺癌马来酸奈拉替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
马来酸奈拉替尼Neratinib Maleate	Tier C — Watch / trade	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

马来酸奈拉替尼原研路线steps: 3total yield: 0.86 g

4-chloro-7-ethoxy-6-nitroquinoline-3-carbonitrile→6-amino-4-chloro-7-ethoxyquinoline-3-carbonitrile→(E)-4-(dimethylamino)but-2-enoyl chloride→(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide→3-chloro-4-(pyridin-2-ylmethoxy)aniline

马来酸奈拉替尼优化路线steps: 6total yield: 154 g

3-chloro-4-(pyridin-2-ylmethoxy)aniline→2-chloro-4-nitrophenol→pyridin-2-ylmethanol→2-((2-chloro-4-nitrophenoxy)methyl)pyridine→N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide→N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide→6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile→(E)-4-(dimethylamino)but-2-enoic acid hydrochloride

马来酸奈拉替尼优化路线steps: 9total yield: 15 mg

3-chloro-4-(pyridin-2-ylmethoxy)aniline→(E)-but-2-enoyl chloride→methyl 3-amino-4-ethoxybenzoate→(E)-methyl 3-(but-2-enamido)-4-ethoxybenzoate→(E)-methyl 5-(but-2-enamido)-4-ethoxy-2-nitrobenzoate→NERT-017→3,3-diethoxypropanenitrile→methyl 5-((E)-but-2-enamido)-2-((2-cyanovinyl)amino)-4-ethoxybenzoate→(E)-N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)but-2-enamide→(E)-N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide→(E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide→(E)-4-bromo-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline Pharmaceutical Intermediates	询价	询价	询价	—

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