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CAS 1420987-77-4
(Z)-3-(2,6-dichlorophenyl)-2-mercaptoacrylic acid
Codes：BREX-016
Application context (from source-drug indications)
精神分裂症布瑞哌唑阿尔茨海默病布瑞哌唑躁动布瑞哌唑抑郁布瑞哌唑抑郁症布瑞哌唑重度抑郁症布瑞哌唑
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 布瑞哌唑Brexpiprazole | Tier A — Act now | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-chloro-6-fluorobenzaldehyde→2-thioxothiazolidin-4-one→(Z)-5-(2,6-dichlorobenzylidene)-2-thioxothiazolidin-4-one→(Z)-3-(2,6-dichlorophenyl)-2-mercaptoacrylic acid→4-chlorobenzo[b]thiophene-2-carboxylic acid→4-chlorobenzo[b]thiophene→7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
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