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CAS 6940-78-9
1-bromo-4-chlorobutane1-溴-4-氯丁烷4-溴氯丁烷4-Bromo-1-chlorobutane
Codes：BREX-002
Physicochemical properties & identification
- Formula
- C4H8BrCl
- Mol. weight
- 171.46
- Appearance
- 无色至淡黄色透明液体
- Density
- 约 1.47 g/cm³（20 °C）
- Solubility
- 不溶于水，与乙醇、乙醚、氯仿混溶
- Storage
- 避光密封阴凉存放；烷基化试剂，操作注意防护
Applications
- · 丁基双官能烷基化试剂：布瑞哌唑侧链（1-氯-4-溴丁烷环节）等 CNS 药物合成
- · 药物分子链接子（linker）与季铵盐前体合成
Application context (from source-drug indications)
精神分裂症布瑞哌唑阿尔茨海默病布瑞哌唑躁动布瑞哌唑抑郁布瑞哌唑抑郁症布瑞哌唑重度抑郁症布瑞哌唑
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 布瑞哌唑Brexpiprazole | Tier A — Act now | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride→4-bromobenzo[b]thiophene→piperazine
2-chloro-6-fluorobenzaldehyde→2-thioxothiazolidin-4-one→(Z)-5-(2,6-dichlorobenzylidene)-2-thioxothiazolidin-4-one→(Z)-3-(2,6-dichlorophenyl)-2-mercaptoacrylic acid→4-chlorobenzo[b]thiophene-2-carboxylic acid→4-chlorobenzo[b]thiophene→7-hydroxyquinolin-2(1H)-one→1-bromo-4-chlorobutane→7-(4-chlorobutoxy)quinolin-2(1H)-one→1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
Intermediates available on this site
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