CAS 1421312-34-6

methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate

Codes：ROXA-019

Application context (from source-drug indications)

贫血罗沙司他

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
罗沙司他Roxadustat	Tier C — Watch / trade	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

罗沙司他优化路线steps: 10total yield: 0.21 g

4-phenoxyphthalic acid→4-nitrophthalonitrile→4-phenoxyphthalonitrile→5-phenoxyisobenzofuran-1,3-dione→methyl 2-cyanoacetate→2-(4-(methoxycarbonyl)oxazol-5-yl)-4-phenoxybenzoic acid→methyl 4-hydroxy-1-oxo-7-phenoxy-1,2-dihydroisoquinoline-3-carboxylate→methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate→methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate→4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid→methyl glycinate hydrochloride→methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate

罗沙司他优化路线steps: 9total yield: /

2-aminoacetic acid→methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate→phenol→5-bromoisobenzofuran-1(3H)-one→5-phenoxyisobenzofuran-1(3H)-one→2-(chloromethyl)-4-phenoxybenzoyl chloride→methyl 2-(chloromethyl)-4-phenoxybenzoate→methyl tosylglycinate→methyl 2-((N-(2-methoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)-4-phenoxybenzoate→methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate→N,N,N',N'-tetramethylmethanediamine→methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate→methyl 1-(acetoxymethyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Pharmaceutical Intermediates	询价	询价	询价	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.