CAS 142678-35-1

(-)-(S)-Pantoprazole

Codes：S-pantoprazole sodium-064

Application context (from source-drug indications)

胃食管反流病（S）-泮托拉唑钠消化性溃疡（S）-泮托拉唑钠出血（S）-泮托拉唑钠创伤和损伤（S）-泮托拉唑钠昏迷（S）-泮托拉唑钠吸入性肺炎（S）-泮托拉唑钠

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
（S）-泮托拉唑钠S-pantoprazole sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

（S）-泮托拉唑钠工艺路线steps: 7total yield: 1.1kg((S)-(-)-Pantoprazole sodium (API))

2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→(-)-(S)-Pantoprazole

（S）-泮托拉唑钠优化路线steps: 5total yield: 54.1g((S)-(-)-Pantoprazole sodium (API))

5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole→1-[5-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one→1-[5-(Difluoromethoxy)-2-[(S)-(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one→(-)-(S)-Pantoprazole

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