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CAS 97963-62-7
5-(Difluoromethoxy)-1H-benzimidazole-2-thiol
Codes：S-pantoprazole sodium-017、S-pantoprazole sodium-050
Application context (from source-drug indications)
胃食管反流病（S）-泮托拉唑钠消化性溃疡（S）-泮托拉唑钠出血（S）-泮托拉唑钠创伤和损伤（S）-泮托拉唑钠昏迷（S）-泮托拉唑钠吸入性肺炎（S）-泮托拉唑钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| （S）-泮托拉唑钠S-pantoprazole sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Acetamidophenol→Chlorodifluoromethane→N-[4-(Difluoromethoxy)phenyl]acetamide→N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide→2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→4-(Difluoromethoxy)-2-nitroaniline→1,2-Diamino-4-(difluoromethoxy)benzene→O-Ethylxanthic acid potassium salt→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→(3,4-Dimethoxypyridin-2-yl)methanol
3-Hydroxy-2-methyl-4H-pyran-4-one→3-Methoxy-2-methyl-4H-pyran-4-one→3-Methoxy-2-methylpyridin-4-one→4-Chloro-3-methoxy-2-methylpyridine→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→4-Chloro-3-methoxy-2-methylpyridine 1-oxide→3,4-Dimethoxy-2-methylpyridine 1-oxide→(3,4-Dimethoxypyridin-2-yl)methanol→2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
4-Acetamidophenol→Chlorodifluoromethane→N-[4-(Difluoromethoxy)phenyl]acetamide→N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide→N-[2-Amino-4-(difluoromethoxy)phenyl]acetamide→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
4-(Difluoromethoxy)-2-nitroaniline→1,2-Diamino-4-(difluoromethoxy)benzene→Carbon disulfide→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→2-(chloromethyl)-3,4-dimethoxypyridine→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→2-(Chloromethyl)-3,4-dimethoxy-1-oxo-1lambda5-pyridine→S-pantoprazole sodium-061
3-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium→(3-methoxy-4-nitropyridin-2-yl)methyl methanesulfonate→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→4-Chloro-3-methoxy-2-methylpyridine 1-oxide→(4-chloro-3-methoxypyridin-2-yl)methyl methanesulfonate→2-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole
2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→5-(Difluoromethoxy)-1H-benzimidazole-2-thiol→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→(-)-(S)-Pantoprazole
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