Unibest 优贝德
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（S）-泮托拉唑钠

Tier C — Watch / trade

S-pantoprazole sodium

Ahn-Gook
Originator
2006
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type

Targets：H+/K+ ATPase

Brand：Letopra、Panpure

Indications (approved)：胃食管反流病、消化性溃疡

Regional status

US
-
EU
-
China
临床一期
2017-05-11
Japan
-

Synthetic routes & intermediates17 routes

Originator routes × 0Optimised (non-patent) × 16Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield 4g((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
S-pantoprazole sodium-001-potassium (ethoxymethanethioyl)sulfanide
S-pantoprazole sodium-002172282-50-71,2-Diamino-4-(difluoromethoxy)benzene
S-pantoprazole sodium-003142470-46-05-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-004169905-10-62-(chloromethyl)-3,4-dimethoxypyridine
S-pantoprazole sodium-005142470-47-15-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole
OptimisedRoute 2Steps 3 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
S-pantoprazole sodium-006104819-52-52-bromo-3,4-dimethoxypyridine
S-pantoprazole sodium-007142488-36-63,4-dimethoxypyridine-2-carbonitrile
S-pantoprazole sodium-008-methyl 3,4-dimethoxypyridine-2-carboxylate
S-pantoprazole sodium-009169905-10-62-(chloromethyl)-3,4-dimethoxypyridine
OptimisedRoute 3Steps 8 · Total yield 2.5g(Pantoprazole (Free))
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
S-pantoprazole sodium-010103-90-24-Acetamidophenol
S-pantoprazole sodium-01175-45-6Chlorodifluoromethane
S-pantoprazole sodium-01222236-11-9N-[4-(Difluoromethoxy)phenyl]acetamide
S-pantoprazole sodium-01397963-75-2N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide
S-pantoprazole sodium-01472830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-01597963-76-34-(Difluoromethoxy)-2-nitroaniline
S-pantoprazole sodium-002172282-50-71,2-Diamino-4-(difluoromethoxy)benzene
S-pantoprazole sodium-016140-89-6O-Ethylxanthic acid potassium salt
S-pantoprazole sodium-01797963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-01972830-08-1(3,4-Dimethoxypyridin-2-yl)methanol
OptimisedRoute 4Steps 10 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
S-pantoprazole sodium-01972830-08-1(3,4-Dimethoxypyridin-2-yl)methanol
S-pantoprazole sodium-0211121-25-12-Methylpyridin-3-ol
S-pantoprazole sodium-02226395-26-63-methoxy-2-methylpyridine
S-pantoprazole sodium-02335392-65-53-methoxy-2-methyl-1-oxidopyridin-1-ium
S-pantoprazole sodium-02415931-25-63-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium
S-pantoprazole sodium-02572830-07-03,4-Dimethoxy-2-methylpyridine 1-oxide
S-pantoprazole sodium-026108-24-7Acetic anhydride
S-pantoprazole sodium-027102625-99-0(3,4-dimethoxypyridin-2-yl)methyl acetate
S-pantoprazole sodium-0207295-76-33-methoxypyridine
S-pantoprazole sodium-0281956319-26-84-Chloro-3-methoxypyridine hydrochloride
S-pantoprazole sodium-029617-35-62-Oxopropionic acid ethyl ester
S-pantoprazole sodium-0301261741-83-6ethyl 4-chloro-3-methoxypyridine-2-carboxylate
S-pantoprazole sodium-031-methyl 3,4-dimethoxypyridine-2-carboxylate
OptimisedRoute 5Steps 12 · Total yield 61.88g(Pantoprazole (Free))
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
S-pantoprazole sodium-004169905-10-62-(chloromethyl)-3,4-dimethoxypyridine
S-pantoprazole sodium-032854278-84-52-(3,4-dimethoxypyridin-2-yl)acetonitrile
S-pantoprazole sodium-033854278-85-6methyl 2-(3,4-dimethoxypyridin-2-yl)acetate
S-pantoprazole sodium-034854278-86-7methyl 2-bromo-2-(3,4-dimethoxypyridin-2-yl)acetate
S-pantoprazole sodium-0361182314-64-25-(difluoromethyl)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-037-methyl 2-{[5-(difluoromethyl)-1H-benzimidazol-2-yl]sulfanyl}-2-(3,4-dimethoxypyridin-2-yl)acetate
S-pantoprazole sodium-038-2-{[5-(difluoromethyl)-1H-benzimidazol-2-yl]sulfanyl}-2-(3,4-dimethoxypyridin-2-yl)acetamide
S-pantoprazole sodium-039-2-[5-(difluoromethyl)-1H-benzimidazole-2-sulfinyl]-2-(3,4-dimethoxypyridin-2-yl)acetamide
S-pantoprazole sodium-035854278-90-32-(3,4-dimethoxypyridin-2-yl)acetamide
S-pantoprazole sodium-040854278-91-42-bromo-2-(3,4-dimethoxypyridin-2-yl)acetamide
S-pantoprazole sodium-041-5-(difluoromethyl)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole
OptimisedRoute 6Steps 3 · Total yield 159g((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 6
CodeCAS No.Intermediate
S-pantoprazole sodium-043368890-20-42-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole
S-pantoprazole sodium-044409098-86-82-[[(4-Chloro-3-methoxypyridin-2-yl)methane]sulfinyl]-5-(difluoromethoxy)-1H-benzimidazole
S-pantoprazole sodium-045102625-70-75-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
OptimisedRoute 7Steps 11 · Total yield 5.2g((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 7
CodeCAS No.Intermediate
S-pantoprazole sodium-046118-71-83-Hydroxy-2-methyl-4H-pyran-4-one
S-pantoprazole sodium-0474780-14-73-Methoxy-2-methyl-4H-pyran-4-one
S-pantoprazole sodium-04876015-11-73-Methoxy-2-methylpyridin-4-one
S-pantoprazole sodium-049107512-34-54-Chloro-3-methoxy-2-methylpyridine
S-pantoprazole sodium-05097963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-025122307-41-94-Chloro-3-methoxy-2-methylpyridine 1-oxide
S-pantoprazole sodium-01972830-07-03,4-Dimethoxy-2-methylpyridine 1-oxide
S-pantoprazole sodium-01472830-08-1(3,4-Dimethoxypyridin-2-yl)methanol
S-pantoprazole sodium-01772830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-045102625-70-75-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
OptimisedRoute 8Steps 3 · Total yield 25g(S-pantoprazole sodium-025)
Synthetic routes & intermediates Route 8
CodeCAS No.Intermediate
S-pantoprazole sodium-046118-71-83-Hydroxy-2-methyl-4H-pyran-4-one
S-pantoprazole sodium-02572830-07-03,4-Dimethoxy-2-methylpyridine 1-oxide
S-pantoprazole sodium-051-3-Hydroxy-2-methylpyridin-4(1H)-one
S-pantoprazole sodium-052107512-35-63,4-Dimethoxy-2-methylpyridine
OptimisedRoute 9Steps 2 · Total yield 209g((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 9
CodeCAS No.Intermediate
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-045102625-70-75-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
OptimisedRoute 10Steps 6 · Total yield /
Synthetic routes & intermediates Route 10
CodeCAS No.Intermediate
S-pantoprazole sodium-010103-90-24-Acetamidophenol
S-pantoprazole sodium-01175-45-6Chlorodifluoromethane
S-pantoprazole sodium-01222236-11-9N-[4-(Difluoromethoxy)phenyl]acetamide
S-pantoprazole sodium-01397963-75-2N-[4-(Difluoromethoxy)-2-nitrophenyl]acetamide
S-pantoprazole sodium-053780782-96-9N-[2-Amino-4-(difluoromethoxy)phenyl]acetamide
S-pantoprazole sodium-01797963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-01472830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
OptimisedRoute 11Steps 1 · Total yield /
Synthetic routes & intermediates Route 11
CodeCAS No.Intermediate
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-054142706-18-1(+)-5-(Difluoromethoxy)-2-[(R)-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole
OptimisedRoute 12Steps 4 · Total yield 7g(Pantoprazole (Free))
Synthetic routes & intermediates Route 12
CodeCAS No.Intermediate
S-pantoprazole sodium-01472830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-05562-56-6AvailableAminothiocarboxamide
S-pantoprazole sodium-056179116-74-6(3,4-Dimethoxypyridin-2-yl)methyl hydrosulfide
S-pantoprazole sodium-057541-41-3Chloridocarbonic acid ethyl ester
S-pantoprazole sodium-058-Ethyl (3,4-dimethoxy-2-pyridyl)methylsulfanylformate
S-pantoprazole sodium-002172282-50-71,2-Diamino-4-(difluoromethoxy)benzene
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-045102625-70-75-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
OptimisedRoute 13Steps 3 · Total yield 2.83g(Pantoprazole (Free))
Synthetic routes & intermediates Route 13
CodeCAS No.Intermediate
S-pantoprazole sodium-01597963-76-34-(Difluoromethoxy)-2-nitroaniline
S-pantoprazole sodium-002172282-50-71,2-Diamino-4-(difluoromethoxy)benzene
S-pantoprazole sodium-05975-15-0Carbon disulfide
S-pantoprazole sodium-01797963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-01472830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-004169905-10-62-(chloromethyl)-3,4-dimethoxypyridine
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-060953787-47-82-(Chloromethyl)-3,4-dimethoxy-1-oxo-1lambda5-pyridine
S-pantoprazole sodium-061953787-51-4-
OptimisedRoute 14Steps 6 · Total yield 65g(Pantoprazole (Free))
Synthetic routes & intermediates Route 14
CodeCAS No.Intermediate
S-pantoprazole sodium-02415931-25-63-methoxy-2-methyl-4-nitro-1-oxido-1-pyridin-1-ylium
S-pantoprazole sodium-062368890-16-8(3-methoxy-4-nitropyridin-2-yl)methyl methanesulfonate
S-pantoprazole sodium-01797963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-050122307-41-94-Chloro-3-methoxy-2-methylpyridine 1-oxide
S-pantoprazole sodium-063368890-18-0(4-chloro-3-methoxypyridin-2-yl)methyl methanesulfonate
S-pantoprazole sodium-043368890-20-42-[[(4-Chloro-3-methoxypyridin-2-yl)methyl]sulfanyl]-5-(difluoromethoxy)-1H-benzimidazole
OptimisedRoute 15Steps 1 · Total yield /
Synthetic routes & intermediates Route 15
CodeCAS No.Intermediate
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
OptimisedRoute 17Steps 5 · Total yield 54.1g((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 17
CodeCAS No.Intermediate
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-045102625-70-75-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
S-pantoprazole sodium-065-1-[5-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one
S-pantoprazole sodium-066-1-[5-(Difluoromethoxy)-2-[(S)-(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl]ethan-1-one
S-pantoprazole sodium-064142678-35-1(-)-(S)-Pantoprazole
ProcessRoute 16Steps 7 · Total yield 1.1kg((S)-(-)-Pantoprazole sodium (API))
Synthetic routes & intermediates Route 16
CodeCAS No.Intermediate
S-pantoprazole sodium-01472830-09-22-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride
S-pantoprazole sodium-01797963-62-75-(Difluoromethoxy)-1H-benzimidazole-2-thiol
S-pantoprazole sodium-018102625-64-95-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole
S-pantoprazole sodium-064142678-35-1(-)-(S)-Pantoprazole

Frequently asked questions

What are the approved indications of S-pantoprazole sodium?

Approved indications include: 胃食管反流病, 消化性溃疡.

When does the S-pantoprazole sodium patent expire?

No public expiry year is available for S-pantoprazole sodium yet; this page updates once verified.

How many synthesis routes are recorded for S-pantoprazole sodium?

17 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy S-pantoprazole sodium intermediates?

1 intermediate CAS of S-pantoprazole sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for S-pantoprazole sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24