CAS 143782-23-4

4-isothiocyanato-2-(trifluoromethyl)benzonitrile

Codes：ENZA-007

Application context (from source-drug indications)

激素敏感性前列腺肿瘤恩扎卢胺去势抵抗性前列腺肿瘤恩扎卢胺前列腺癌恩扎卢胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
恩扎卢胺Enzalutamide	Tier A — Act now	2027

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

恩扎卢胺原研路线steps: 5total yield: 15 mg

2-fluoro-1-methyl-4-nitrobenzene→2-fluoro-4-nitrobenzoic acid→2-fluoro-N-methyl-4-nitrobenzamide→4-amino-2-fluoro-N-methylbenzamide→2-hydroxy-2-methylpropanenitrile→4-((2-cyanopropan-2-yl)amino)-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile

恩扎卢胺优化路线steps: 4total yield: 213.9 g

4-isothiocyanato-2-(trifluoromethyl)benzonitrile→4-bromo-2-fluorobenzoic acid→4-bromo-2-fluoro-N-methylbenzamide→2-amino-2-methylpropanoic acid→2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid→methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate

恩扎卢胺优化路线steps: 2total yield: 152.3 g

4-amino-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile→methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate→methyl 2-bromo-2-methylpropanoate

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.