← Back to patent-cliff list
CAS 150728-12-4
5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione
Codes: BOSE-013
Application context (from source-drug indications)
溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Bosentan Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione→potassium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide→2-(tert-butoxy)ethanol→N-(6-(2-(tert-butoxy)ethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)-4-(tert-butyl)benzenesulfonamide→2-((6-((4-(tert-butyl)phenyl)sulfonamido)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)oxy)ethyl formate
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione→potassium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide→pyrimidine-2-carbonitrile→dimethyl 2-(2-methoxyphenoxy)malonate→2,2-diethoxyethan-1-ol→4-(tert-butyl)-N-(6-(2,2-diethoxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide→4-(tert-butyl)-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.