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CAS 150726-89-9
dimethyl 2-(2-methoxyphenoxy)malonate
Codes: CLAZ-003, BOSE-019
Application context (from source-drug indications)
动脉瘤Clazosentan SodiumIntracranial vasospasmClazosentan SodiumSubarachnoid haemorrhageClazosentan SodiumCerebral infarctionClazosentan Sodium脑缺血Clazosentan Sodium溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Clazosentan Sodium | Tier C — Watch / trade | - |
| Bosentan Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
isonicotinonitrile→isonicotinimidamide hydrochloride→dimethyl 2-(2-methoxyphenoxy)malonate→5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine-4,6-diol→4,6-dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine→4-(4,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-2-yl)pyridine 1-oxide→potassium ((5-methylpyridin-2-yl)sulfonyl)amide→4-(4-chloro-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→4-(4-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→N-(2-(2-cyanopyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione→potassium ((4-(tert-butyl)phenyl)sulfonyl)(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)amide→pyrimidine-2-carbonitrile→dimethyl 2-(2-methoxyphenoxy)malonate→2,2-diethoxyethan-1-ol→4-(tert-butyl)-N-(6-(2,2-diethoxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide→4-(tert-butyl)-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
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