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CAS 1571-08-0
methyl 4-formylbenzoate
Codes：PRAL-010
Application context (from source-drug indications)
外周T细胞淋巴瘤普拉曲沙T-细胞淋巴瘤普拉曲沙实体瘤普拉曲沙血液肿瘤普拉曲沙B-细胞淋巴瘤普拉曲沙皮肤T细胞淋巴瘤普拉曲沙
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 普拉曲沙Pralatrexate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→methyl 4-formylbenzoate→methyl 5'-methyl-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 4-(6-oxohept-1-yn-4-yl)benzoate→dimethyl carbonate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→(E)-4-(7-(hydroxyimino)-6-oxohept-1-yn-4-yl)benzoic acid→pyrimidine-2,4,5,6-tetraamine hydrochloride→di-tert-butyl L-glutamate→di-tert-butyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
methyl 4-formylbenzoate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→methyl (E)-4-(3-oxobut-1-en-1-yl)benzoate→dimethyl malonate→sodium 2,4'-bis(methoxycarbonyl)-5-oxo-1,2,5,6-tetrahydro-[1,1'-biphenyl]-3-olate→5'-hydroxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid→methyl 5'-methoxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 5'-chloro-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→sodium (Z)-4-methoxy-4-oxobut-2-en-2-olate→methyl 5'-(2-methoxy-2-oxoethyl)-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→4-nitrobenzenesulfonohydrazide
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