普拉曲沙
Tier C — Watch / tradePralatrexate
Targets：DHFR
Brand：Folotyn、Difolta
Indications (approved)：外周T细胞淋巴瘤
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAL-001 | 52787-14-1 | methyl 4-(2-methoxy-2-oxoethyl)benzoate |
| PRAL-002 | 106-96-7 | 3-bromoprop-1-yne |
| PRAL-003 | 146464-90-6 | methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate |
| PRAL-004 | 59368-16-0 | 6-(bromomethyl)pteridine-2,4-diamine |
| PRAL-005 | 146464-91-7 | methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate |
| PRAL-006 | 146464-92-8 | 4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid |
| PRAL-007 | 146464-93-9 | 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid |
| PRAL-008 | 1118-89-4 | (S)-diethyl 2-aminopentanedioate hydrochloride |
| PRAL-009 | 146464-94-0 | diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAL-007 | 146464-93-9 | 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid |
| PRAL-010 | 1571-08-0 | methyl 4-formylbenzoate |
| PRAL-011 | 1480887-37-3 | methyl 5'-methyl-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate |
| PRAL-012 | - | methyl 4-(6-oxohept-1-yn-4-yl)benzoate |
| PRAL-013 | 616-38-6 | dimethyl carbonate |
| PRAL-014 | 1480887-43-1 | methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate |
| PRAL-015 | 1480887-45-3 | (E)-4-(7-(hydroxyimino)-6-oxohept-1-yn-4-yl)benzoic acid |
| PRAL-016 | 65540-06-9 | pyrimidine-2,4,5,6-tetraamine hydrochloride |
| PRAL-017 | 16874-06-9 | di-tert-butyl L-glutamate |
| PRAL-018 | 1480887-48-6 | di-tert-butyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAL-010 | 1571-08-0 | methyl 4-formylbenzoate |
| PRAL-014 | 1480887-43-1 | methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate |
| PRAL-019 | 115665-93-5 | methyl (E)-4-(3-oxobut-1-en-1-yl)benzoate |
| PRAL-020 | 108-59-8Available | dimethyl malonate |
| PRAL-021 | 1480887-51-1 | sodium 2,4'-bis(methoxycarbonyl)-5-oxo-1,2,5,6-tetrahydro-[1,1'-biphenyl]-3-olate |
| PRAL-022 | 1480887-54-4 | 5'-hydroxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid |
| PRAL-023 | 1480887-56-6 | methyl 5'-methoxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate |
| PRAL-024 | 1480887-58-8 | methyl 5'-chloro-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate |
| PRAL-025 | - | sodium (Z)-4-methoxy-4-oxobut-2-en-2-olate |
| PRAL-026 | 1480887-60-2 | methyl 5'-(2-methoxy-2-oxoethyl)-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate |
| PRAL-027 | 2937-05-5 | 4-nitrobenzenesulfonohydrazide |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAL-028 | 1452584-67-6 | dimethyl (4-(6,7-dioxohept-1-yn-4-yl)benzoyl)-L-glutamate |
| PRAL-029 | 1452584-66-5 | (4-(6,7-dioxohept-1-yn-4-yl)benzoyl)-L-glutamic acid |
| PRAL-030 | 52980-67-3 | pyrimidine-2,4,5,6-tetraamine dihydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRAL-001 | 52787-14-1 | methyl 4-(2-methoxy-2-oxoethyl)benzoate |
| PRAL-002 | 106-96-7 | 3-bromoprop-1-yne |
| PRAL-003 | 146464-90-6 | methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate |
| PRAL-004 | 59368-16-0 | 6-(bromomethyl)pteridine-2,4-diamine |
| PRAL-009 | 146464-94-0 | diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate |
| PRAL-031 | 1548618-47-8 | methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate hydrobromide |
| PRAL-032 | 146464-92-8 | 4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid |
| PRAL-033 | 1445586-50-4 | sodium 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate |
| PRAL-034 | 16450-41-2 | (S)-diethyl 2-aminopentanedioate |
Frequently asked questions
What are the approved indications of Pralatrexate?
Approved indications include: 外周T细胞淋巴瘤.
When does the Pralatrexate patent expire?
No public expiry year is available for Pralatrexate yet; this page updates once verified.
How many synthesis routes are recorded for Pralatrexate?
5 synthesis routes are recorded; the shortest is 2 steps with 1.92 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pralatrexate intermediates?
1 intermediate CAS of Pralatrexate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pralatrexate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24