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CAS 169960-20-7

5-amino-2-{[(6R,7R)-7-amino-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-(2-hydroxyethyl)-1H-pyrazol-2-ium

Codes:Cefoselis Sulfate-031

Application context (from source-drug indications)

细菌感染硫酸头孢噻利

Source drugs (routes using this intermediate)

DrugTierExpiry
硫酸头孢噻利Cefoselis SulfateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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硫酸头孢噻利优化路线steps: 3total yield: 2.18g(Cefoselis Sulfate (API))
4-Chloro-2(Z)-(methoxyimino)-3-oxobutyric acid→5-amino-2-{[(6R,7R)-7-amino-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-(2-hydroxyethyl)-1H-pyrazol-2-ium→3-amino-1-{[(6R,7R)-2-carboxylato-7-[(2Z)-4-chloro-2-(methoxyimino)-3-oxobutanamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-2-(2-hydroxyethyl)-2H-pyrazol-1-ium→Sulfourea→(6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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