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硫酸头孢噻利
Tier C — Watch / tradeCefoselis Sulfate
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Originator
2006
First approval
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Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：PBPs
Brand：Wincef
Indications (approved)：细菌感染
Regional status
US
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EU
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China
批准上市
2006-01-28
Japan
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Synthetic routes & intermediates5 routes
Originator routes × 0Optimised (non-patent) × 4Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 7 · Total yield 6.53g(Cefoselis Sulfate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefoselis Sulfate-001 | 73616-27-0 | 2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol |
| Cefoselis Sulfate-002 | 116856-18-9 | 2-[5-(Formylamino)-1H-pyrazol-1-yl]ethyl formate |
| Cefoselis Sulfate-003 | 112028-91-8 | Diphenylmethyl (6R,7R)-7-[(tert-butoxycarbonyl)amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefoselis Sulfate-004 | - | 2-([(6R,7R)-7-[(tert-Butoxycarbonyl)amino]-2-[(diphenylmethoxy)carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl)-5-(formylamino)-1-[2-(formyloxy)ethyl]-1H-pyrazol-2-ium iodide |
| Cefoselis Sulfate-005 | - | (6R,7R)-7-Amino-3-[[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride |
| Cefoselis Sulfate-006 | 83594-38-1 | (2Z)-[2-(Formylamino)-1,3-thiazol-4-yl](methoxyimino)ethanoic acid |
| Cefoselis Sulfate-007 | - | (6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-[2-(formylamino)-1,3-thiazol-4-yl]-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefoselis Sulfate-008 | 1120365-56-1 | (6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefoselis Sulfate-009 | 78162-04-6 | 1-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]-3-oxido-1H-1,2,3-benzotriazol-3-ium |
OptimisedRoute 2Steps 10 · Total yield 231. 2g(Cefoselis Sulfate-001)
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefoselis Sulfate-001 | 73616-27-0 | 2-(5-Amino-1H-pyrazol-1-yl)ethan-1-ol |
| Cefoselis Sulfate-010 | 68-12-2 | N,N-Dimethylformamide |
| Cefoselis Sulfate-011 | 105-34-0Available | 2-Cyanoacetic acid methyl ester |
| Cefoselis Sulfate-012 | 105-56-6Available | 2-Cyanoacetic acid ethyl ester |
| Cefoselis Sulfate-013 | 14447-15-5 | Propyl cyanoacetate |
| Cefoselis Sulfate-014 | 5459-58-5 | Butyl cyanoacetate |
| Cefoselis Sulfate-015 | 1187-27-5 | Methyl 2-cyano-3-(dimethylamino)prop-2-enoate |
| Cefoselis Sulfate-016 | 16849-87-9 | Ethyl 2-cyano-3-(dimethylamino)prop-2-enoate |
| Cefoselis Sulfate-017 | - | Propyl 2-cyano-3-(dimethylamino)prop-2-enoate |
| Cefoselis Sulfate-018 | - | Butyl 2-cyano-3-(dimethylamino)prop-2-enoate |
| Cefoselis Sulfate-019 | 109-84-2 | 2-Hydrazinoethanol |
| Cefoselis Sulfate-020 | 170019-55-3 | Methyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate |
| Cefoselis Sulfate-021 | 58046-49-4 | Ethyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate |
| Cefoselis Sulfate-022 | - | Propyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate |
| Cefoselis Sulfate-023 | - | Butyl 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylate |
| Cefoselis Sulfate-024 | 58046-50-7 | 5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid |
| Cefoselis Sulfate-025 | 1119-85-3 | Hex-3-enedinitrile |
| Cefoselis Sulfate-026 | 109-75-1 | But-3-enenitrile |
| Cefoselis Sulfate-027 | 6162-76-1 | 3-Oxopropanenitrile |
| Cefoselis Sulfate-028 | 57597-62-3 | 3,3-Dimethoxypropanenitrile |
| Cefoselis Sulfate-029 | - | 3-[2-(2-Hydroxyethyl)hydrazinylidene]propanenitrile |
OptimisedRoute 3Steps 3 · Total yield 2.18g(Cefoselis Sulfate (API))
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefoselis Sulfate-030 | 111230-59-2 | 4-Chloro-2(Z)-(methoxyimino)-3-oxobutyric acid |
| Cefoselis Sulfate-031 | 169960-20-7 | 5-amino-2-{[(6R,7R)-7-amino-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-(2-hydroxyethyl)-1H-pyrazol-2-ium |
| Cefoselis Sulfate-032 | - | 3-amino-1-{[(6R,7R)-2-carboxylato-7-[(2Z)-4-chloro-2-(methoxyimino)-3-oxobutanamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-2-(2-hydroxyethyl)-2H-pyrazol-1-ium |
| Cefoselis Sulfate-033 | 62-56-6Available | Sulfourea |
| Cefoselis Sulfate-008 | 1120365-56-1 | (6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
OptimisedRoute 5Steps 4 · Total yield 117g(Cefoselis Sulfate (FREE))
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefoselis Sulfate-037 | 957-68-6 | (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Cefoselis Sulfate-038 | 106134-67-2 | Trimethylsilyl (6R,7R)-3-(iodomethyl)-8-oxo-7-[(trimethylsilyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefoselis Sulfate-002 | 116856-18-9 | 2-[5-(Formylamino)-1H-pyrazol-1-yl]ethyl formate |
| Cefoselis Sulfate-005 | - | (6R,7R)-7-Amino-3-[[5-amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride |
| Cefoselis Sulfate-039 | 80756-85-0 | S-(benzo[d]thiazol-2-yl) (Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate |
| Cefoselis Sulfate-008 | 1120365-56-1 | (6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
ProcessRoute 4Steps 2 · Total yield 417g(Cefoselis Sulfate-036)
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefoselis Sulfate-034 | 104146-10-3 | (6R,7R)-3-(Chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester |
| Cefoselis Sulfate-035 | 113479-65-5 | 4-Methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride |
| Cefoselis Sulfate-036 | 134866-27-6 | 4-Methoxybenzyl (6R,7R)-7-[(tert-butoxycarbonyl)amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
Frequently asked questions
What are the approved indications of Cefoselis Sulfate?
Approved indications include: 细菌感染.
When does the Cefoselis Sulfate patent expire?
No public expiry year is available for Cefoselis Sulfate yet; this page updates once verified.
How many synthesis routes are recorded for Cefoselis Sulfate?
5 synthesis routes are recorded; the shortest is 2 steps with 417g(Cefoselis Sulfate-036) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cefoselis Sulfate intermediates?
3 intermediate CAS of Cefoselis Sulfate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Cefoselis Sulfate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24