CAS 22115-41-9

(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate

Codes：ALOG-002

Application context (from source-drug indications)

二型糖尿病苯甲酸阿格列汀糖尿病苯甲酸阿格列汀急性冠脉综合征苯甲酸阿格列汀

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
苯甲酸阿格列汀Alogliptin Benzoate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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苯甲酸阿格列汀原研路线steps: 8total yield: /

6-chloropyrimidine-2,4(1H,3H)-dione→(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate→2-((6-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-piperidin-3-amine dihydrochloride→(R)-2,5-diaminopentanoic acid hydrochloride→(R)-methyl 2,5-diaminopentanoate→(R)-3-aminopiperidin-2-one hydrochloride→(R)-piperidin-3-amine hydrochloride

苯甲酸阿格列汀优化路线steps: 5total yield: /

6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-piperidin-3-amine dihydrochloride→isobenzofuran-1,3-dione

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	2-Cyanobenzyl bromide Pharmaceutical Intermediates	询价	询价	询价	—

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