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CAS 2401852-78-4

N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide

Codes: (XXVc)796686-1-d

Application context (from source-drug indications)

侵袭性念珠菌病Rezafungin acetateCandidiasisRezafungin acetateCandidaemiaRezafungin acetate卡氏肺囊虫感染Rezafungin acetate侵袭性真菌感染Rezafungin acetateAspergillus infectionRezafungin acetate

Source drugs (routes using this intermediate)

DrugTierExpiry
Rezafungin acetateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Rezafungin acetateOptimised routesteps: 2total yield: /
(11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide→Methyl iodide→3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-phenyl-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-[4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(2,6-Dimethylphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→2-Hydroxy-N,N,N-trimethylethylammonium chloride→2-[[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-yl]oxy]-N,N,N-trimethylethan-1-aminium→2-(Dimethylamino)ethanol hydrochloride

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