CAS 247068-85-5

(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate

Codes：CARF-011

Application context (from source-drug indications)

多发性骨髓瘤卡非佐米

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
卡非佐米Carfilzomib	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

卡非佐米原研路线steps: 10total yield: 0.08 g

(tert-butoxycarbonyl)-L-leucine→benzyl L-phenylalaninate→benzyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→(S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid→benzyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-(((S)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-4-phenylbutan-2-aminium 2,2,2-trifluoroacetate→2-morpholinoacetic acid→benzyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine→(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate→2-bromoprop-1-ene→tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate→tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

卡非佐米优化路线steps: 11total yield: 13.5 g

(tert-butoxycarbonyl)-L-leucine→(S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid→((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine→(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate→tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate→tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate→(S)-methyl 2-amino-3-phenylpropanoate→methyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→methyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→2-chloroacetyl chloride→methyl ((S)-2-(2-chloroacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→morpholine→methyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→N,O-dimethylhydroxylamine hydrochloride→prop-1-en-2-ylmagnesium bromide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI) Pharmaceutical Intermediates	询价	询价	询价	—

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