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CAS 314771-76-1
(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Codes：AFAT-008
Application context (from source-drug indications)
非小细胞肺癌马来酸阿法替尼头颈部鳞状细胞癌马来酸阿法替尼头颈癌马来酸阿法替尼脊索瘤马来酸阿法替尼鳞状细胞癌马来酸阿法替尼胆囊癌马来酸阿法替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马来酸阿法替尼Afatinib Dimaleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-amino-4-fluoro-5-nitrobenzoic acid→N-(4-((3-chloro-4-fluorophenyl)(3,4-dimethoxybenzyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide→3-chloro-N-(3,4-dimethoxybenzyl)-4-fluoroaniline→3-chloro-4-fluoroaniline→N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→(E)-4-bromobut-2-enoic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→2-amino-4-chlorobenzoic acid→7-chloroquinazolin-4(3H)-one→7-chloro-6-nitroquinazolin-4(4aH)-one→4,7-dichloro-6-nitroquinazoline→N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine→2-(diethoxyphosphoryl)acetic acid→(S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate→2,2-diethoxy-N,N-dimethylethanamine→maleic acid
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