马来酸阿法替尼
Tier C — Watch / tradeAfatinib Dimaleate
Targets：HER4、EGFR、HER2、EGFR L858R、EGFR 19del
Brand：Giotrif、Tovok、Tomtovok、吉泰瑞、Gilotrif
Indications (approved)：非小细胞肺癌
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| AFAT-001 | 1194097-41-0 | 2-amino-4-fluoro-5-nitrobenzoic acid |
| AFAT-002 | 162012-69-3 | N-(4-((3-chloro-4-fluorophenyl)(3,4-dimethoxybenzyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide |
| AFAT-003 | 162012-70-6 | 3-chloro-N-(3,4-dimethoxybenzyl)-4-fluoroaniline |
| AFAT-004 | 367-21-5 | 3-chloro-4-fluoroaniline |
| AFAT-005 | 162012-67-1Available | N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine |
| AFAT-006 | 86087-23-2Available | (S)-tetrahydrofuran-3-ol |
| AFAT-007 | 314771-88-5 | (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine |
| AFAT-008 | 314771-76-1 | (S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine |
| AFAT-009 | 13991-36-1 | (E)-4-bromobut-2-enoic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| AFAT-004 | 367-21-5 | 3-chloro-4-fluoroaniline |
| AFAT-006 | 86087-23-2Available | (S)-tetrahydrofuran-3-ol |
| AFAT-007 | 314771-88-5 | (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine |
| AFAT-008 | 314771-76-1 | (S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine |
| AFAT-010 | - | 2-amino-4-chlorobenzoic acid |
| AFAT-011 | 31374-18-2 | 7-chloroquinazolin-4(3H)-one |
| AFAT-012 | 53449-14-2 | 7-chloro-6-nitroquinazolin-4(4aH)-one |
| AFAT-013 | 162012-71-7 | 4,7-dichloro-6-nitroquinazoline |
| AFAT-014 | 945553-94-6 | N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine |
| AFAT-015 | 3095-95-2 | 2-(diethoxyphosphoryl)acetic acid |
| AFAT-016 | 618061-76-0 | (S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate |
| AFAT-017 | 3616-56-6 | 2,2-diethoxy-N,N-dimethylethanamine |
| AFAT-018 | 110-16-7Available | maleic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| AFAT-004 | 367-21-5 | 3-chloro-4-fluoroaniline |
| AFAT-006 | 86087-23-2Available | (S)-tetrahydrofuran-3-ol |
| AFAT-019 | 536-25-4 | methyl 3-amino-4-hydroxybenzoate |
| AFAT-020 | 1454655-89-0 | methyl 5-amino-4-hydroxy-2-nitrobenzoate |
| AFAT-021 | 1454656-00-8 | methyl 2,5-diamino-4-hydroxybenzoate |
| AFAT-022 | 1156986-96-7 | 6-amino-7-hydroxyquinazolin-4(3H)-one |
| AFAT-023 | 1451008-28-8 | 6-amino-4-chloroquinazolin-7-ol |
| AFAT-024 | 1451008-29-9 | (S)-4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-amine |
| AFAT-025 | 1056149-69-9 | (E)-4-(dimethylamino)but-2-enoyl chloride |
| AFAT-026 | 1451008-30-2 | (S,E)-N-(4-chloro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| AFAT-004 | 367-21-5 | 3-chloro-4-fluoroaniline |
| AFAT-006 | 86087-23-2Available | (S)-tetrahydrofuran-3-ol |
| AFAT-025 | 1056149-69-9 | (E)-4-(dimethylamino)but-2-enoyl chloride |
| AFAT-027 | 767-00-0 | 4-hydroxybenzonitrile |
| AFAT-028 | 3272-08-0Available | 4-hydroxy-3-nitrobenzonitrile |
| AFAT-029 | 1451012-56-8 | (S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile |
| AFAT-030 | 1451012-57-9 | (S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile |
| AFAT-031 | 1637330-92-7 | (S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide |
| AFAT-032 | 1637330-93-8 | (S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide |
| AFAT-033 | 1451369-97-3 | (S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide |
| AFAT-034 | 1451369-98-4 | (E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide |
Frequently asked questions
What are the approved indications of Afatinib Dimaleate?
Approved indications include: 非小细胞肺癌.
When does the Afatinib Dimaleate patent expire?
No public expiry year is available for Afatinib Dimaleate yet; this page updates once verified.
How many synthesis routes are recorded for Afatinib Dimaleate?
4 synthesis routes are recorded; the shortest is 6 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Afatinib Dimaleate intermediates?
4 intermediate CAS of Afatinib Dimaleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Afatinib Dimaleate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24