CAS 41202-77-1

1-(2,3-dichlorophenyl)piperazine

Codes：CARI-016

Application context (from source-drug indications)

重度抑郁症卡利拉嗪盐酸盐精神分裂症卡利拉嗪盐酸盐躁狂症卡利拉嗪盐酸盐

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
卡利拉嗪盐酸盐Cariprazine Hydrochloride	Tier A — Act now	2029

Position in synthesis routes (up/downstream chain)

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卡利拉嗪盐酸盐优化路线steps: 7total yield: 29.9 g

dimethylcarbamic chloride→4-aminocyclohexanone→1,1-dimethyl-3-(4-oxocyclohexyl)urea→ethyl 2-(diethoxyphosphoryl)acetate→ethyl 2-(4-(3,3-dimethylureido)cyclohexylidene)acetate→ethyl 2-((1r,4r)-4-(3,3-dimethylureido)cyclohexyl)acetate→3-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-1,1-dimethylurea→1,1-dimethyl-3-((1r,4r)-4-(2-oxoethyl)cyclohexyl)urea→1-(2,3-dichlorophenyl)piperazine

卡利拉嗪盐酸盐优化路线steps: 8total yield: 76 mg

tert-butyl ((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate→1-(2,3-dichlorophenyl)piperazine→2-(4-nitrophenyl)acetic acid→ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride→ethyl 2-((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)acetate→tert-butyl ((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)carbamate→(1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine→N-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1H-imidazole-1-carboxamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	1-(2,3-Dichlorophenyl)-piperazine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—

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